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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4c3f 7KW Tyrosine-protein kinase Lck 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4c3f 7KWTyrosine-protein kinase Lck 2.7.10.2 0.915
4fv7 E94Mitogen-activated protein kinase 1 2.7.11.24 0.705
4d4s BI9Focal adhesion kinase 1 2.7.10.2 0.694
4ase AV9Vascular endothelial growth factor receptor 2 2.7.10.1 0.687
4fux E75Mitogen-activated protein kinase 1 2.7.11.24 0.687
3uzp 0CKCasein kinase I isoform delta 2.7.11.1 0.681
2itp AEEEpidermal growth factor receptor 2.7.10.1 0.679
4a4l 939Serine/threonine-protein kinase PLK1 2.7.11.21 0.679
2itt AEEEpidermal growth factor receptor 2.7.10.1 0.675
2vwx 7X4Ephrin type-B receptor 4 2.7.10.1 0.672
4aot GW8Serine/threonine-protein kinase 10 2.7.11.1 0.671
2xb7 GUIALK tyrosine kinase receptor 2.7.10.1 0.669
4fko 20KCyclin-dependent kinase 2 2.7.11.22 0.668
2ivu ZD6Proto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.667
2jko BIJFocal adhesion kinase 1 2.7.10.2 0.667
3cjg KIMVascular endothelial growth factor receptor 2 2.7.10.1 0.667
3zsg T75Mitogen-activated protein kinase 14 / 0.667
3w33 W19Epidermal growth factor receptor 2.7.10.1 0.666
4lop SB4Mitogen-activated protein kinase 14 / 0.666
2wih P48Cyclin-dependent kinase 2 2.7.11.22 0.665
3sw4 18KCyclin-dependent kinase 2 2.7.11.22 0.665
3qlg 1N1Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.664
3unk 0BYCyclin-dependent kinase 2 2.7.11.22 0.664
2vww 7X2Ephrin type-B receptor 4 2.7.10.1 0.659
2vwz 7X6Ephrin type-B receptor 4 2.7.10.1 0.659
2x9f X9FEphrin type-B receptor 4 2.7.10.1 0.656
1y57 MPZProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.655
2yac 937Serine/threonine-protein kinase PLK1 2.7.11.21 0.655
2vx0 7X7Ephrin type-B receptor 4 2.7.10.1 0.654
2xvd AS6Ephrin type-B receptor 4 2.7.10.1 0.654
4bbe 3O4Tyrosine-protein kinase JAK2 / 0.653
5amn DTQProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.653
1urw I1PCyclin-dependent kinase 2 2.7.11.22 0.652
3sw7 19KCyclin-dependent kinase 2 2.7.11.22 0.651
2jkq VG8Focal adhesion kinase 1 2.7.10.2 0.650