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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4c34 STU cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4c34 STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.193
1u59 STUTyrosine-protein kinase ZAP-70 2.7.10.2 0.905
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.894
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 0.844
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.835
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.822
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.819
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.819
1stc STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.808
4mvf STUCalcium-dependent protein kinase 2 2.7.11.1 0.789
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.782
5e8x STUTGF-beta receptor type-1 2.7.11.30 0.781
1qpd STUTyrosine-protein kinase Lck 2.7.10.2 0.780
3cbl STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.780
5e8y STUTGF-beta receptor type-2 2.7.11.30 0.780
3a62 STURibosomal protein S6 kinase beta-1 2.7.11.1 0.777
4yzc STUSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.774
1qpj STUTyrosine-protein kinase Lck 2.7.10.2 0.771
1nvs UCMSerine/threonine-protein kinase Chk1 2.7.11.1 0.767
2j0j 4STFocal adhesion kinase 1 2.7.10.2 0.762
1byg STUTyrosine-protein kinase CSK / 0.760
2gcd STUSerine/threonine-protein kinase TAO2 2.7.11.1 0.759
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.758
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.757
1oky STU3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.752
3bkb STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.752
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
3ckx STUSerine/threonine-protein kinase 24 2.7.11.1 0.744
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.737
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.731
2yn8 STUEphrin type-B receptor 4 2.7.10.1 0.730
1yvj 4STTyrosine-protein kinase JAK3 2.7.10.2 0.715
4fr4 STUSerine/threonine-protein kinase 32A 2.7.11.1 0.715
4qmy STUSerine/threonine-protein kinase 24 2.7.11.1 0.715
3a60 STURibosomal protein S6 kinase beta-1 2.7.11.1 0.711
2hy8 1STSerine/threonine-protein kinase PAK 1 2.7.11.1 0.709
3d7t STUTyrosine-protein kinase CSK / 0.708
1snu STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.705
4erw STUCyclin-dependent kinase 2 2.7.11.22 0.690
1xjd STUProtein kinase C theta type 2.7.11.13 0.686
4kik KSAInhibitor of nuclear factor kappa-B kinase subunit beta 2.7.11.10 0.683
3f69 XDRSerine/threonine-protein kinase PknB 2.7.11.1 0.676
3c4e C4ESerine/threonine-protein kinase pim-1 2.7.11.1 0.671
3zls 92PDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.664
4e5f 0N7Polymerase acidic protein / 0.660
1ydr IQPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
3vqh IQBcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657