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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bzb DGT Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4bzb DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.277
4qfx DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.230
4qfy DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.167
4to3 DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.050
4to2 DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.035
4to4 DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.033
4to1 DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.999
4to0 DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.996
4qfz TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.970
4qg1 DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.965
4mz7 DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.930
4to6 TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.903
4to5 DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.901
4qg0 DUTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.895
4tny DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.858
4rxp DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.852
4rxr DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.823
4rxs TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.810
4tnz TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.785
4rxq DUTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.769
4zwe DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.701
4brg GNPEctonucleoside triphosphate diphosphohydrolase I / 0.670
1n75 ATPGlutamate--tRNA ligase 6.1.1.17 0.668
4to0 DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.665
4yj2 GTPTubulin alpha-1B chain / 0.665
4bri UNPEctonucleoside triphosphate diphosphohydrolase I / 0.662
4b8w GDPGDP-L-fucose synthase 1.1.1.271 0.661
3w2w ATPCRISPR system Cmr subunit Cmr2 / 0.660
4qfy DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.660
4to3 DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.657
3rye UNRFarnesyl pyrophosphate synthase 2.5.1.10 0.654
4a4w YFBPeroxisome proliferator-activated receptor gamma / 0.654
1rc1 KT3Trifunctional purine biosynthetic protein adenosine-3 2.1.2.2 0.653
3rbm B73Farnesyl pyrophosphate synthase, putative / 0.652
4tnp DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.652
3x1z GNPRas-related protein Rap-1b / 0.651