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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4buv 16I Tankyrase-2 2.4.2.30

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4buv 16ITankyrase-2 2.4.2.30 0.953
4bu9 08CTankyrase-2 2.4.2.30 0.913
4bus 32FTankyrase-2 2.4.2.30 0.913
4but 31FTankyrase-2 2.4.2.30 0.900
4bux F35Tankyrase-2 2.4.2.30 0.892
4bud 29FTankyrase-2 2.4.2.30 0.883
3kr8 XAVTankyrase-2 2.4.2.30 0.865
4buu F38Tankyrase-2 2.4.2.30 0.862
4bue JQFTankyrase-2 2.4.2.30 0.858
4l0s 1UZTankyrase-2 2.4.2.30 0.855
4buf F36Tankyrase-2 2.4.2.30 0.852
4l10 A63Tankyrase-2 2.4.2.30 0.852
4l34 1VGTankyrase-2 2.4.2.30 0.850
4buw F33Tankyrase-2 2.4.2.30 0.847
4kzu A73Tankyrase-2 2.4.2.30 0.846
4hlm 16STankyrase-2 2.4.2.30 0.839
4l0t 1V0Tankyrase-2 2.4.2.30 0.838
5aku 29FTankyrase-2 2.4.2.30 0.835
4hki FLNTankyrase-2 2.4.2.30 0.834
4l09 1URTankyrase-2 2.4.2.30 0.834
4kzl 20DTankyrase-2 2.4.2.30 0.831
4bs4 A64Tankyrase-2 2.4.2.30 0.830
4bui W2ETankyrase-2 2.4.2.30 0.830
4l0v 1V1Tankyrase-2 2.4.2.30 0.829
4hlh 20DTankyrase-2 2.4.2.30 0.822
4hlf 15ZTankyrase-2 2.4.2.30 0.821
4hlg 20BTankyrase-2 2.4.2.30 0.816
4avw G18Tankyrase-2 2.4.2.30 0.807
4l33 F70Tankyrase-2 2.4.2.30 0.804
4l2k 1V8Tankyrase-2 2.4.2.30 0.802
4hlk 431Tankyrase-2 2.4.2.30 0.799
4l0i 1UWTankyrase-2 2.4.2.30 0.796
4hkk AGITankyrase-2 2.4.2.30 0.792
4l32 1VFTankyrase-2 2.4.2.30 0.787
4msg 2C6Tankyrase-1 2.4.2.30 0.785
4hkn LU2Tankyrase-2 2.4.2.30 0.774
4l2f 1V3Tankyrase-2 2.4.2.30 0.773
4hmh F94Tankyrase-2 2.4.2.30 0.772
4avu LDRTankyrase-2 2.4.2.30 0.766
4hl5 15WTankyrase-2 2.4.2.30 0.766
4l2g 1V4Tankyrase-2 2.4.2.30 0.761
4l31 F08Tankyrase-2 2.4.2.30 0.761
3u9y 09LTankyrase-2 2.4.2.30 0.740
4bjb P34Tankyrase-2 2.4.2.30 0.740
4gv0 8MEPoly [ADP-ribose] polymerase 3 2.4.2.30 0.740
4mt9 2D6Tankyrase-1 2.4.2.30 0.732
4bjc RPBTankyrase-2 2.4.2.30 0.728
4gv4 MEJPoly [ADP-ribose] polymerase 3 2.4.2.30 0.726
4msk 2C8Tankyrase-1 2.4.2.30 0.721
4pnr G18Tankyrase-2 2.4.2.30 0.721
4pnm NU1Tankyrase-2 2.4.2.30 0.716
4li6 1XOTankyrase-1 2.4.2.30 0.715
4tjy 3GNTankyrase-2 2.4.2.30 0.713
3c49 KU8Poly [ADP-ribose] polymerase 3 2.4.2.30 0.711
4gv2 5MEPoly [ADP-ribose] polymerase 3 2.4.2.30 0.709
3c4h DRLPoly [ADP-ribose] polymerase 3 2.4.2.30 0.705
3p0p NNFTankyrase-2 2.4.2.30 0.705
4i9i 1DYTankyrase-1 2.4.2.30 0.705
4r5w XAVPoly [ADP-ribose] polymerase 1 2.4.2.30 0.700
3gn7 3GNPoly [ADP-ribose] polymerase 1 2.4.2.30 0.687
2rd6 78PPoly [ADP-ribose] polymerase 1 2.4.2.30 0.684
4gv7 MEWPoly [ADP-ribose] polymerase 1 2.4.2.30 0.680
5ds3 09LPoly [ADP-ribose] polymerase 1 2.4.2.30 0.671
5ewk P34Putative secreted protein / 0.671
4li8 1XQTankyrase-1 2.4.2.30 0.670
4tkg 09LTankyrase-2 2.4.2.30 0.670
5dsy UHBPoly [ADP-ribose] polymerase 2 2.4.2.30 0.670
3l3m A92Poly [ADP-ribose] polymerase 1 2.4.2.30 0.669
4bj9 UHBTankyrase-2 2.4.2.30 0.668
4hhz 15SPoly [ADP-ribose] polymerase 1 2.4.2.30 0.668
4j3l AJ5Tankyrase-2 2.4.2.30 0.668
4iue AJ4Tankyrase-2 2.4.2.30 0.665
2rcw AAIPoly [ADP-ribose] polymerase 1 2.4.2.30 0.661
4e5f 0N7Polymerase acidic protein / 0.660
4e5i 0N9Polymerase acidic protein / 0.660
4j3m AJ8Tankyrase-2 2.4.2.30 0.655
4f1l 0RYPoly [ADP-ribose] polymerase 14 2.4.2.30 0.653