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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bqy FNT Egl nine homolog 1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4bqy FNTEgl nine homolog 1 / 1.000
2g1m 4HGEgl nine homolog 1 / 0.838
4bqw QNMEgl nine homolog 1 / 0.741
4nhm UN9Prolyl 3,4-dihydroxylase TPA1 1.14.11 0.740
4ie5 MD6Alpha-ketoglutarate-dependent dioxygenase FTO / 0.714
4i13 FOLDihydrofolate reductase 1.5.1.3 0.675
3tqb FOLDihydrofolate reductase / 0.667
1arg PPDAspartate aminotransferase 2.6.1.1 0.666
1df7 MTXDihydrofolate reductase 1.5.1.3 0.666
1u4s BIHL-lactate dehydrogenase 1.1.1.27 0.666
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.665
1e26 GPBDihydrofolate reductase 1.5.1.3 0.662
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.661
4x5i FOLDihydrofolate reductase 1.5.1.3 0.661
4bb3 KKAIsopenicillin N synthase 1.21.3.1 0.656
4bqs K2QShikimate kinase 2.7.1.71 0.655
4dbc 3QPAspartate aminotransferase 2.6.1.1 0.655
1x28 PGUAspartate aminotransferase 2.6.1.1 0.654
3qpg 3QPAspartate aminotransferase 2.6.1.1 0.654
4l8u 9AZSerum albumin / 0.653
1cl2 PPGCystathionine beta-lyase MetC 4.4.1.8 0.651
1gir NDPIota toxin component Ia / 0.651
1dra MTXDihydrofolate reductase 1.5.1.3 0.650
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.650
4ew2 DXYTrifunctional purine biosynthetic protein adenosine-3 2.1.2.2 0.650