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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bix ADP Sensor histidine kinase CpxA

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4bix ADPSensor histidine kinase CpxA / 0.894
4biz ADPSensor histidine kinase CpxA / 0.754
1id0 ANPSensor protein PhoQ 2.7.13.3 0.731
2c2a ADPSensor histidine kinase / 0.725
4jau ADPSensor histidine kinase / 0.722
1jm6 ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.709
2e0a ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.709
3a0t ADPSensor histidine kinase / 0.704
1i5b ANPChemotaxis protein CheA 2.7.13.3 0.694
4biw ANPSensor histidine kinase CpxA / 0.694
3d2r ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.693
4prx ADPDNA gyrase subunit B / 0.691
1gjv AGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial 2.7.11.4 0.688
1i58 ADPChemotaxis protein CheA 2.7.13.3 0.686
3crl ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.686
1i59 ANPChemotaxis protein CheA 2.7.13.3 0.684
4prv ADPDNA gyrase subunit B / 0.683
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.681
2zdy ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.679
2zkj ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.678
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.676
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.673
1i58 ACPChemotaxis protein CheA 2.7.13.3 0.672
4xc0 ACPHeat shock cognate 90 kDa protein / 0.672
5f5r ANPHeat shock protein 75 kDa, mitochondrial / 0.672
2bu8 ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.671
3t0z ATPHeat shock protein HSP 90-alpha / 0.671
4wuc ANPDNA gyrase subunit B / 0.671
3ehj ACPSensor histidine kinase DesK 2.7.13.3 0.669
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.666
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.665
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.665
2gs7 ANPEpidermal growth factor receptor 2.7.10.1 0.664
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.660
1s16 ANPDNA topoisomerase 4 subunit B / 0.660
4fl3 ANPTyrosine-protein kinase SYK 2.7.10.2 0.660
4gt3 ATPMitogen-activated protein kinase 1 2.7.11.24 0.660
2ior ADPChaperone protein HtpG / 0.659
2itx ANPEpidermal growth factor receptor 2.7.10.1 0.659
4gt8 ADPSensor protein VraS 2.7.13.3 0.658
4pl9 ADPEthylene receptor 1 / 0.658
4xcj ADPHeat shock cognate 90 kDa protein / 0.658
3dge ADPSensor histidine kinase / 0.657
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.656
4ts7 ADPPurine phosphoribosyltransferase (GpT-1) / 0.656
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.655
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.654
4xcl AGSHeat shock cognate 90 kDa protein / 0.654
1z59 ADPType 2 DNA topoisomerase 6 subunit B / 0.653
1ho5 ADNProtein UshA 3.1.3.5 0.652
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.652
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.651
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
1wc1 TATAdenylate cyclase / 0.650
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.650
2g2f AGSTyrosine-protein kinase ABL1 2.7.10.2 0.650
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650