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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bgq 38R Cyclin-dependent kinase-like 5 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4bgq 38RCyclin-dependent kinase-like 5 2.7.11.22 1.038
1vyw 292Cyclin-dependent kinase 2 2.7.11.22 0.786
4ek6 10KCyclin-dependent kinase 2 2.7.11.22 0.734
2vn9 GVDCalcium/calmodulin-dependent protein kinase type II subunit delta 2.7.11.17 0.727
3zdu 38RCyclin-dependent kinase-like 3 2.7.11.22 0.724
3dog NNNCyclin-dependent kinase 2 2.7.11.22 0.716
4fkg 4CKCyclin-dependent kinase 2 2.7.11.22 0.707
3ddq RRCCyclin-dependent kinase 2 2.7.11.22 0.701
1vyz N5BCyclin-dependent kinase 2 2.7.11.22 0.699
2wpa 889Cyclin-dependent kinase 2 2.7.11.22 0.698
3amb VX6cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.678
3pj8 404Cyclin-dependent kinase 2 2.7.11.22 0.678
4f64 0S8Fibroblast growth factor receptor 1 / 0.675
4f63 0S7Fibroblast growth factor receptor 1 / 0.674
3le6 2BZCyclin-dependent kinase 2 2.7.11.22 0.672
3ggf GVDSerine/threonine-protein kinase 26 / 0.671
4lyn 1YGCyclin-dependent kinase 2 2.7.11.22 0.671
2x1n X1NCyclin-dependent kinase 2 2.7.11.22 0.670
3e5a VX6Aurora kinase A 2.7.11.1 0.665
4agu D15Cyclin-dependent kinase-like 1 / 0.665
2f2c AP9Cyclin-dependent kinase 6 2.7.11.22 0.662
4jbq VX6Aurora kinase A 2.7.11.1 0.659
4o0r X4ZSerine/threonine-protein kinase PAK 1 2.7.11.1 0.658
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.655
4nks 2M2Fibroblast growth factor receptor 1 / 0.651