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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bgh 3I6 Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4bgh 3I6Cyclin-dependent kinase 2 2.7.11.22 0.980
1urw I1PCyclin-dependent kinase 2 2.7.11.22 0.768
2xmy CDKCyclin-dependent kinase 2 2.7.11.22 0.768
3r9o Z71Cyclin-dependent kinase 2 2.7.11.22 0.761
3rpy 27ZCyclin-dependent kinase 2 2.7.11.22 0.758
3sw4 18KCyclin-dependent kinase 2 2.7.11.22 0.742
4fkv 61KCyclin-dependent kinase 2 2.7.11.22 0.733
2c6o 4SPCyclin-dependent kinase 2 2.7.11.22 0.728
3sw7 19KCyclin-dependent kinase 2 2.7.11.22 0.725
2wxv WXVCyclin-dependent kinase 2 2.7.11.22 0.723
2vtj LZ4Cyclin-dependent kinase 2 2.7.11.22 0.722
2wip P49Cyclin-dependent kinase 2 2.7.11.22 0.721
4ji9 1M3Tyrosine-protein kinase JAK2 / 0.721
2jko BIJFocal adhesion kinase 1 2.7.10.2 0.714
4fx3 60KCyclin-dependent kinase 2 2.7.11.22 0.713
1pxm CK5Cyclin-dependent kinase 2 2.7.11.22 0.709
1ke5 LS1Cyclin-dependent kinase 2 2.7.11.22 0.708
3lfq A28Cyclin-dependent kinase 2 2.7.11.22 0.705
1fvt 106Cyclin-dependent kinase 2 2.7.11.22 0.704
1oit HDTCyclin-dependent kinase 2 2.7.11.22 0.702
2vti LZ3Cyclin-dependent kinase 2 2.7.11.22 0.700
4fks 46KCyclin-dependent kinase 2 2.7.11.22 0.700
3tiz 3TICyclin-dependent kinase 2 2.7.11.22 0.697
3qrt X14Cyclin-dependent kinase 2 2.7.11.22 0.696
1ke6 LS2Cyclin-dependent kinase 2 2.7.11.22 0.695
2wih P48Cyclin-dependent kinase 2 2.7.11.22 0.695
3i5z Z48Mitogen-activated protein kinase 1 2.7.11.24 0.694
2iw8 4SPCyclin-dependent kinase 2 2.7.11.22 0.693
3le6 2BZCyclin-dependent kinase 2 2.7.11.22 0.691
1h1s 4SPCyclin-dependent kinase 2 2.7.11.22 0.690
2xnb Y8LCyclin-dependent kinase 2 2.7.11.22 0.690
3qtx X43Cyclin-dependent kinase 2 2.7.11.22 0.690
2r3q 5SCCyclin-dependent kinase 2 2.7.11.22 0.688
2j9m PY8Cyclin-dependent kinase 2 2.7.11.22 0.684
2p33 J07Mitogen-activated protein kinase 10 2.7.11.24 0.684
1gih 1PUCyclin-dependent kinase 2 2.7.11.22 0.683
3i60 E86Mitogen-activated protein kinase 1 2.7.11.24 0.683
2jkk BI9Focal adhesion kinase 1 2.7.10.2 0.682
3pj8 404Cyclin-dependent kinase 2 2.7.11.22 0.682
2b55 D31Cyclin-dependent kinase 2 2.7.11.22 0.681
2xck MH43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.680
3s1h 56ZCyclin-dependent kinase 2 2.7.11.22 0.680
4fkp LS5Cyclin-dependent kinase 2 2.7.11.22 0.679
1gii 1PUCyclin-dependent kinase 2 2.7.11.22 0.678
2x1n X1NCyclin-dependent kinase 2 2.7.11.22 0.677
2xch CKG3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.675
2r3l SCWCyclin-dependent kinase 2 2.7.11.22 0.674
3cjf SAVVascular endothelial growth factor receptor 2 2.7.10.1 0.674
3rmf 20ZCyclin-dependent kinase 2 2.7.11.22 0.674
3qtu X44Cyclin-dependent kinase 2 2.7.11.22 0.673
2jkq VG8Focal adhesion kinase 1 2.7.10.2 0.672
4fkt 48KCyclin-dependent kinase 2 2.7.11.22 0.671
1ckp PVBCyclin-dependent kinase 2 2.7.11.22 0.670
2b54 D05Cyclin-dependent kinase 2 2.7.11.22 0.669
2iw6 QQ2Cyclin-dependent kinase 2 2.7.11.22 0.669
3h3c P1EProtein-tyrosine kinase 2-beta 2.7.10.2 0.667
4d4s BI9Focal adhesion kinase 1 2.7.10.2 0.667
3uo5 0BXAurora kinase A 2.7.11.1 0.666
4fkw 62KCyclin-dependent kinase 2 2.7.11.22 0.666
1pxo CK7Cyclin-dependent kinase 2 2.7.11.22 0.664
3rak 03ZCyclin-dependent kinase 2 2.7.11.22 0.664
4eor 4SPCyclin-dependent kinase 2 2.7.11.22 0.664
4fkq 42KCyclin-dependent kinase 2 2.7.11.22 0.664
3r8v Z62Cyclin-dependent kinase 2 2.7.11.22 0.662
2a0c CK9Cyclin-dependent kinase 2 2.7.11.22 0.661
2r3r 6SCCyclin-dependent kinase 2 2.7.11.22 0.661
1ke8 LS4Cyclin-dependent kinase 2 2.7.11.22 0.660
2c5n CK8Cyclin-dependent kinase 2 2.7.11.22 0.658
3ezr EZRCyclin-dependent kinase 2 2.7.11.22 0.658
1oec AA2Fibroblast growth factor receptor 2 / 0.657
2x4f 16XMyosin light chain kinase family member 4 2.7.11.1 0.657
3ezv EZVCyclin-dependent kinase 2 2.7.11.22 0.655
4fv6 E57Mitogen-activated protein kinase 1 2.7.11.24 0.655
3ql8 X01Cyclin-dependent kinase 2 2.7.11.22 0.654