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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bfm ANP Maternal embryonic leucine zipper kinase 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.995
3nie ANPMitogen-activated protein kinase / 0.816
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.798
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.776
3llt ANPProtein serine/threonine kinase-1 / 0.775
3orm AGSSerine/threonine protein kinase / 0.765
3orp AGSSerine/threonine protein kinase / 0.764
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.761
2pun ACPMethylthioribose kinase 2.7.1.100 0.757
3ori AGSSerine/threonine protein kinase / 0.756
3ort AGSSerine/threonine protein kinase / 0.750
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.740
2pyw ADPMethylthioribose kinase 2.7.1.100 0.737
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.734
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.732
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.731
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.730
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.727
2py3 ACPFibroblast growth factor receptor 2 / 0.726
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.725
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.725
4o4d ATPKinase / 0.725
2pui ADPMethylthioribose kinase 2.7.1.100 0.724
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.724
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.721
2pul ACPMethylthioribose kinase 2.7.1.100 0.720
3a8w ATPProtein kinase C iota type 2.7.11.13 0.718
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.716
5dr2 ATPAurora kinase A 2.7.11.1 0.715
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.713
3cly ACPFibroblast growth factor receptor 2 / 0.712
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.706
2pup ADPMethylthioribose kinase 2.7.1.100 0.705
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.705
4dee ADPAurora kinase A 2.7.11.1 0.705
5drd ATPAurora kinase A 2.7.11.1 0.704
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.703
4bn1 ADPAurora kinase A 2.7.11.1 0.701
3c4z ADPRhodopsin kinase / 0.699
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.699
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.698
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.698
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.697
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.697
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.697
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.697
3c50 ADPRhodopsin kinase / 0.696
3qc9 ADPRhodopsin kinase / 0.696
4fg7 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.695
3ork AGSSerine/threonine protein kinase / 0.694
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.694
1u54 ACPActivated CDC42 kinase 1 / 0.693
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.693
5l8k ADPAurora kinase A 2.7.11.1 0.693
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.691
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.691
3t8o ATPRhodopsin kinase / 0.690
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.690
5dnr ATPAurora kinase A 2.7.11.1 0.689
4xlv ACPInsulin receptor 2.7.10.1 0.688
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.687
2olc ADPMethylthioribose kinase 2.7.1.100 0.687
2yaa ATPDeath-associated protein kinase 2 / 0.687
3c4w ATPRhodopsin kinase / 0.687
1ol6 ATPAurora kinase A 2.7.11.1 0.685
1ol5 ADPAurora kinase A 2.7.11.1 0.684
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.684
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.684
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.684
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.683
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.683
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.683
2dwb ANPAurora kinase A 2.7.11.1 0.682
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.682
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.682
4q5h ANPProtein kinase OspG 2.7 0.682
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.681
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.681
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.680
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.680
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.680
3orl AGSSerine/threonine protein kinase / 0.679
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
4ysj ADPCalmodulin-like domain protein kinase / 0.679
1mq4 ADPAurora kinase A 2.7.11.1 0.678
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.678
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.678
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.677
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.677
4n57 ADPAPH(2'')-Id / 0.677
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.677
3mfu ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.676
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.675
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.675
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.675
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.675
4fl3 ANPTyrosine-protein kinase SYK 2.7.10.2 0.675
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.674
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
5dos ATPAurora kinase A 2.7.11.1 0.673
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.672
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.672
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.671
4ceg ADPAurora kinase A 2.7.11.1 0.671
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.670
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.668
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.668
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.668
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.667
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.667
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.667
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.666
5dt3 ATPAurora kinase A 2.7.11.1 0.666
2pml ANPUncharacterized protein / 0.664
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.664
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.664
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.663
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.663
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.661
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.661
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.660
3lmh ADPMyosin heavy chain kinase A 2.7.11.7 0.660
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.659
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.659
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.658
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.657
2cjm ATPCyclin-dependent kinase 2 2.7.11.22 0.657
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.656
3oro AGSSerine/threonine protein kinase / 0.656
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.656
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.656
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.656
4c3p ACPAurora kinase A 2.7.11.1 0.655
4mv8 ACPBiotin carboxylase 6.3.4.14 0.655
2vqd AP2Biotin carboxylase 6.3.4.14 0.654
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.654
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.654
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.654
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
4utd ACPAurora kinase A 2.7.11.1 0.654
5dn3 ATPAurora kinase A 2.7.11.1 0.653
3bu5 ATPInsulin receptor 2.7.10.1 0.652
4o4e ATPKinase / 0.652
4ock ANPN-acetylhexosamine 1-kinase 2.7.1.162 0.652
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.651
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.651
2eb3 ANPEpidermal growth factor receptor 2.7.10.1 0.650