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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bfd 8T3 Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4bfd 8T3Beta-secretase 1 3.4.23.46 0.961
4j17 1HQBeta-secretase 1 3.4.23.46 0.829
4j1e 1HMBeta-secretase 1 3.4.23.46 0.817
4j1h 1HJBeta-secretase 1 3.4.23.46 0.809
4j0p 1H8Beta-secretase 1 3.4.23.46 0.805
4j0y 1H6Beta-secretase 1 3.4.23.46 0.796
4j0t 6T9Beta-secretase 1 3.4.23.46 0.795
4j1k 1HGBeta-secretase 1 3.4.23.46 0.771
4j0v 1H7Beta-secretase 1 3.4.23.46 0.767
4j1c 1HOBeta-secretase 1 3.4.23.46 0.757
4j0z 1H5Beta-secretase 1 3.4.23.46 0.754
4j1f 1HLBeta-secretase 1 3.4.23.46 0.754
3zki WZVBeta-secretase 2 3.4.23.45 0.751
4j1i 1HHBeta-secretase 1 3.4.23.46 0.747
3zks WZVBeta-secretase 2 3.4.23.45 0.743
3zmg 6Z0Beta-secretase 1 3.4.23.46 0.739
3zov WZVBeta-secretase 1 3.4.23.46 0.734
3zlq 6T9Beta-secretase 2 3.4.23.45 0.718
4frs 0V6Beta-secretase 1 3.4.23.46 0.695
4fs4 H24Beta-secretase 1 3.4.23.46 0.659
4l7h 1W1Beta-secretase 1 3.4.23.46 0.651