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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bek XK0 Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4bek XK0Beta-secretase 1 3.4.23.46 0.823
3zov WZVBeta-secretase 1 3.4.23.46 0.710
4j0t 6T9Beta-secretase 1 3.4.23.46 0.702
3wb4 0B3Beta-secretase 1 3.4.23.46 0.687
4j1k 1HGBeta-secretase 1 3.4.23.46 0.681
3zkn WZVBeta-secretase 2 3.4.23.45 0.673
3wb5 0B4Beta-secretase 1 3.4.23.46 0.671
4j1f 1HLBeta-secretase 1 3.4.23.46 0.670
4l7g 1W0Beta-secretase 1 3.4.23.46 0.664
2ohl 2AQBeta-secretase 1 3.4.23.46 0.650