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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bdi HAU Serine/threonine-protein kinase Chk2 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4bdi HAUSerine/threonine-protein kinase Chk2 2.7.11.1 0.836
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4jaj XU1Aurora kinase A 2.7.11.1 0.677
4bdh WVISerine/threonine-protein kinase Chk2 2.7.11.1 0.669
3zly YSODual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.668
4c4j X21Dual specificity protein kinase TTK 2.7.12.1 0.668
4fv6 E57Mitogen-activated protein kinase 1 2.7.11.24 0.667
4gmy 0X5Tyrosine-protein kinase JAK2 / 0.664
4e5f 0N7Polymerase acidic protein / 0.660
4gih 0X5Non-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.659
4c4i X20Dual specificity protein kinase TTK 2.7.12.1 0.657
4gj2 0XHNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.657
3i60 E86Mitogen-activated protein kinase 1 2.7.11.24 0.656
2wtj WTJSerine/threonine-protein kinase Chk2 2.7.11.1 0.655
4c4h 7RODual specificity protein kinase TTK 2.7.12.1 0.652
4ans VGHALK tyrosine kinase receptor 2.7.10.1 0.651