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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bcn T9N Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4bcn T9NCyclin-dependent kinase 2 2.7.11.22 0.908
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4bcp T3CCyclin-dependent kinase 2 2.7.11.22 0.732
1oi9 N20Cyclin-dependent kinase 2 2.7.11.22 0.686
4bco T6QCyclin-dependent kinase 2 2.7.11.22 0.677
4bcm T7ZCyclin-dependent kinase 2 2.7.11.22 0.674
2wxv WXVCyclin-dependent kinase 2 2.7.11.22 0.669
1oit HDTCyclin-dependent kinase 2 2.7.11.22 0.668
3ezv EZVCyclin-dependent kinase 2 2.7.11.22 0.663
2etm 7PYFocal adhesion kinase 1 2.7.10.2 0.662
4bcq TJFCyclin-dependent kinase 2 2.7.11.22 0.662
4e5f 0N7Polymerase acidic protein / 0.660
1fvt 106Cyclin-dependent kinase 2 2.7.11.22 0.658
3tiz 3TICyclin-dependent kinase 2 2.7.11.22 0.657
2b53 D23Cyclin-dependent kinase 2 2.7.11.22 0.652