Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4b8m VX6 Aurora kinase B-A 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4b8m VX6Aurora kinase B-A 2.7.11.1 1.043
3e5a VX6Aurora kinase A 2.7.11.1 0.832
4jbq VX6Aurora kinase A 2.7.11.1 0.805
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
3w16 P9JAurora kinase A 2.7.11.1 0.698
3amb VX6cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
4af3 VX6Aurora kinase B 2.7.11.1 0.674
3nlb 5BESerine/threonine-protein kinase Chk1 2.7.11.1 0.671
4e5f 0N7Polymerase acidic protein / 0.660
2vn9 GVDCalcium/calmodulin-dependent protein kinase type II subunit delta 2.7.11.17 0.659
4f64 0S8Fibroblast growth factor receptor 1 / 0.659
4fkg 4CKCyclin-dependent kinase 2 2.7.11.22 0.657
4f63 0S7Fibroblast growth factor receptor 1 / 0.656
4fkj 11KCyclin-dependent kinase 2 2.7.11.22 0.655
1vyz N5BCyclin-dependent kinase 2 2.7.11.22 0.654
2qhn 582Serine/threonine-protein kinase Chk1 2.7.11.1 0.654
3vf8 0JETyrosine-protein kinase SYK 2.7.10.2 0.653