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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4b72 2FB Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4b72 2FBBeta-secretase 1 3.4.23.46 1.013
4acx S8ZBeta-secretase 1 3.4.23.46 0.851
4b77 54MBeta-secretase 1 3.4.23.46 0.835
4b1d 6TGBeta-secretase 1 3.4.23.46 0.824
4b78 KGGBeta-secretase 1 3.4.23.46 0.803
4djw 0KPBeta-secretase 1 3.4.23.46 0.790
4fri DWABeta-secretase 1 3.4.23.46 0.787
4djy 0KRBeta-secretase 1 3.4.23.46 0.766
4djv 0KMBeta-secretase 1 3.4.23.46 0.759
4dju 0KKBeta-secretase 1 3.4.23.46 0.757
4azy 7F3Beta-secretase 1 3.4.23.46 0.745
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4jp9 1M5Beta-secretase 1 3.4.23.46 0.727
3l5e BDWBeta-secretase 1 3.4.23.46 0.692
4jpe 1M7Beta-secretase 1 3.4.23.46 0.687
4b05 32DBeta-secretase 1 3.4.23.46 0.684
4b0q GMFBeta-secretase 1 3.4.23.46 0.684
3h0b B35Beta-secretase 1 3.4.23.46 0.678
4h3j 10WBeta-secretase 1 3.4.23.46 0.663
4e5f 0N7Polymerase acidic protein / 0.660
4joo 1M4Beta-secretase 1 3.4.23.46 0.656
4jpc 1M6Beta-secretase 1 3.4.23.46 0.656
2q15 3MRBeta-secretase 1 3.4.23.46 0.654
1vaf ARRNitric oxide synthase, inducible 1.14.13.39 0.653