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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4b1c 1B1 Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4b1c 1B1Beta-secretase 1 3.4.23.46 0.867
4acu QN7Beta-secretase 1 3.4.23.46 0.721
4b00 I6XBeta-secretase 1 3.4.23.46 0.712
4djy 0KRBeta-secretase 1 3.4.23.46 0.711
4djx 0KQBeta-secretase 1 3.4.23.46 0.708
4djv 0KMBeta-secretase 1 3.4.23.46 0.700
4acx S8ZBeta-secretase 1 3.4.23.46 0.688
4jpc 1M6Beta-secretase 1 3.4.23.46 0.684
4b05 32DBeta-secretase 1 3.4.23.46 0.680
4b1e 6T6Beta-secretase 1 3.4.23.46 0.680
4jp9 1M5Beta-secretase 1 3.4.23.46 0.663
4jpe 1M7Beta-secretase 1 3.4.23.46 0.663
4j1k 1HGBeta-secretase 1 3.4.23.46 0.662
4frs 0V6Beta-secretase 1 3.4.23.46 0.661
4b70 WM9Beta-secretase 1 3.4.23.46 0.660
4fs4 H24Beta-secretase 1 3.4.23.46 0.659
4b0q GMFBeta-secretase 1 3.4.23.46 0.657
4l7h 1W1Beta-secretase 1 3.4.23.46 0.653
4j1h 1HJBeta-secretase 1 3.4.23.46 0.650