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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4axd ANP Inositol-pentakisphosphate 2-kinase 2.7.1.158

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 1.079
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.859
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.821
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.787
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.770
3nie ANPMitogen-activated protein kinase / 0.767
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.750
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.749
3orp AGSSerine/threonine protein kinase / 0.749
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.738
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.735
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.734
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.732
4xlv ACPInsulin receptor 2.7.10.1 0.729
3oro AGSSerine/threonine protein kinase / 0.727
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.723
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.721
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.720
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.719
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.719
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.715
3ort AGSSerine/threonine protein kinase / 0.715
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.714
3tdv GDPGentamicin resistance protein / 0.712
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.712
5ce3 ADPProtein kinase YopO / 0.709
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.704
3ori AGSSerine/threonine protein kinase / 0.703
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.701
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.701
4qny ANPMitogen activated protein kinase, putative / 0.700
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.699
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.699
3c4w ATPRhodopsin kinase / 0.699
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.696
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.694
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.693
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.692
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.690
2p0a ANPSynapsin-3 / 0.689
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.689
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.688
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.684
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.684
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.684
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.683
4ceg ADPAurora kinase A 2.7.11.1 0.681
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.680
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.679
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.678
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.678
3t8o ATPRhodopsin kinase / 0.677
4c3r ACPAurora kinase A 2.7.11.1 0.677
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.676
2pul ACPMethylthioribose kinase 2.7.1.100 0.675
5c1p ADPD-alanine--D-alanine ligase / 0.675
2yaa ATPDeath-associated protein kinase 2 / 0.674
3c50 ADPRhodopsin kinase / 0.674
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.672
3c4z ADPRhodopsin kinase / 0.672
3qc9 ADPRhodopsin kinase / 0.672
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.671
4u0o MTALipoyl synthase 2 / 0.671
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
3bu5 ATPInsulin receptor 2.7.10.1 0.669
4fg7 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.668
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.667
2pz5 ACPFibroblast growth factor receptor 2 / 0.667
3llt ANPProtein serine/threonine kinase-1 / 0.667
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.667
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.665
1u54 ACPActivated CDC42 kinase 1 / 0.665
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.665
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.665
5l8l ADPAurora kinase A 2.7.11.1 0.665
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.663
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.663
2dwb ANPAurora kinase A 2.7.11.1 0.662
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.662
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.662
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.662
5dt4 ATPAurora kinase A 2.7.11.1 0.662
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.661
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.660
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.660
1ir3 ANPInsulin receptor 2.7.10.1 0.659
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.659
3tdw GDPGentamicin resistance protein / 0.658
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
4o4e ATPKinase / 0.658
5dnr ATPAurora kinase A 2.7.11.1 0.658
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.657
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.657
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.657
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
4ffl ADPUncharacterized protein / 0.656
5dos ATPAurora kinase A 2.7.11.1 0.656
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.655
3ork AGSSerine/threonine protein kinase / 0.655
2pyw ADPMethylthioribose kinase 2.7.1.100 0.654
2zdg ADPD-alanine--D-alanine ligase / 0.654
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.653
4ysj ADPCalmodulin-like domain protein kinase / 0.653
3mfu ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.652
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.651
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.651
5dn3 ATPAurora kinase A 2.7.11.1 0.651
5eg3 ACPFibroblast growth factor receptor 2 / 0.651