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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4awt FMN NADH:flavin oxidoreductase Sye1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4awt FMNNADH:flavin oxidoreductase Sye1 / 1.265
4aws FMNNADH:flavin oxidoreductase Sye1 / 1.209
4h6k FMNNADPH dehydrogenase 1 1.6.99.1 1.107
4rnx FMNNADPH dehydrogenase 1 1.6.99.1 1.106
4k7y FMNNADPH dehydrogenase 1 1.6.99.1 1.093
1oya FMNNADPH dehydrogenase 1 1.6.99.1 1.088
4b5n FMNNAD(P)H:flavin oxidoreductase Sye4 / 1.085
4m5p FMNNADPH dehydrogenase / 1.060
1h50 FMNPentaerythritol tetranitrate reductase / 1.057
1vyr FMNPentaerythritol tetranitrate reductase / 1.046
3p8i FMNPentaerythritol tetranitrate reductase / 1.046
3tjl FMNNADPH dehydrogenase / 1.045
3p67 FMNPentaerythritol tetranitrate reductase / 1.044
3p84 FMNPentaerythritol tetranitrate reductase / 1.041
3p8j FMNPentaerythritol tetranitrate reductase / 1.040
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 1.031
3f03 FMNPentaerythritol tetranitrate reductase / 1.024
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 1.019
4tmc FMNOld yellow enzyme / 1.009
4jic FMNGTN Reductase / 1.007
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 1.005
4df2 FMNNADPH dehydrogenase / 0.995
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 0.993
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 0.993
1h51 FMNPentaerythritol tetranitrate reductase / 0.984
3p62 FMNPentaerythritol tetranitrate reductase / 0.984
1h63 FMNPentaerythritol tetranitrate reductase / 0.981
4a3u FMNNADH:flavin oxidoreductase/NADH oxidase / 0.978
1bwl FMNNADPH dehydrogenase 1 1.6.99.1 0.965
1gwj FMNMorphinone reductase / 0.945
2abb FMNPentaerythritol tetranitrate reductase / 0.936
2gou FMNNADH:flavin oxidoreductase Sye1 / 0.934
4rnv FMNNADPH dehydrogenase 1 1.6.99.1 0.924
3aty FMNProstaglandin F2a synthase / 0.918
3p82 FMNPentaerythritol tetranitrate reductase / 0.915
3l67 FMNXenobiotic reductase / 0.909
2hs6 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.907
2gqa FMNNADH:flavin oxidoreductase Sye1 / 0.906
3atz FMNProstaglandin F2a synthase / 0.902
4e2b FMNDehydrogenase / 0.891
4tmb FMNOld yellow enzyme / 0.891
5cpm FNRNADH:flavin oxidoreductase / 0.883
3p74 FMNPentaerythritol tetranitrate reductase / 0.878
4utk FNRXenobiotic reductase / 0.878
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 0.875
4utm FNRXenobiotic reductase / 0.871
4e2d FMNDehydrogenase / 0.867
1z48 FMNNADPH dehydrogenase / 0.864
1z41 FMNNADPH dehydrogenase / 0.862
4xq6 FMNDihydroorotate dehydrogenase (quinone) / 0.860
4ycp FMNtRNA-dihydrouridine(16) synthase / 0.857
2q3r FMN12-oxophytodienoate reductase 1 1.3.1.42 0.855
4uth FMNXenobiotic reductase / 0.853
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 0.850
4qai FMNNADPH dehydrogenase / 0.847
3l5l FMNXenobiotic reductase / 0.843
2djl FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.842
2bsl FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.836
1jue FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.830
3kru FMNNADH:flavin oxidoreductase/NADH oxidase / 0.829
4wzh FMNDihydroorotate dehydrogenase (fumarate) / 0.828
1jub FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.826
3gka FMNN-ethylmaleimide reductase / 0.825
4yco FMNtRNA-dihydrouridine(16) synthase / 0.824
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.823
2h8x FMNXenA / 0.817
1uum FMNDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.815
1vhn FMNtRNA-dihydrouridine synthase / 0.814
4ef8 FMNDihydroorotate dehydrogenase (fumarate) / 0.812
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 0.811
4qnw FMNChanoclavine-I aldehyde reductase easA / 0.807
1z44 FMNNADPH dehydrogenase / 0.801
2hs8 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.801
4utl FNRXenobiotic reductase / 0.800
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 0.799
1q45 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.793
2hsa FMN12-oxophytodienoate reductase 3 1.3.1.42 0.793
4yl2 FMNLactate oxidase / 0.789
1k02 FMNNADPH dehydrogenase 1 1.6.99.1 0.784
3hf3 FMNChromate reductase / 0.781
3c3n FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.778
3vkj FNRIsopentenyl-diphosphate delta-isomerase / 0.774
2zrv FNRIsopentenyl-diphosphate delta-isomerase / 0.768
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 0.768
3n19 FNRXenobiotic reductase / 0.768
3n14 FMNXenobiotic reductase / 0.767
1ep3 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.764
4rnu FMNNADPH dehydrogenase 1 1.6.99.1 0.762
4ef9 FMNDihydroorotate dehydrogenase (fumarate) / 0.761
2e77 FMNLactate oxidase / 0.753
4rje FNRLactate oxidase / 0.753
2zfa FMNLactate oxidase / 0.751
1szf FMNCytochrome b2, mitochondrial 1.1.2.3 0.750
3oix FMNDihydroorotate dehydrogenase / 0.748
2djx FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.747
4bf9 FMNtRNA-dihydrouridine(16) synthase / 0.742
2gjl FMNNitronate monooxygenase 1.13.12.16 0.725
2zry FNRIsopentenyl-diphosphate delta-isomerase / 0.721
1kbj FMNCytochrome b2, mitochondrial 1.1.2.3 0.719
3b05 FNRIsopentenyl-diphosphate delta-isomerase / 0.719
2j6x FMNLactate oxidase / 0.718
2zrx FMNIsopentenyl-diphosphate delta-isomerase / 0.718
2nli FMNLactate oxidase / 0.716
1kbi FMNCytochrome b2, mitochondrial 1.1.2.3 0.713
2zrz FNRIsopentenyl-diphosphate delta-isomerase / 0.707
4cw5 FMNDfnA / 0.697
4yx6 FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.693
1ofd FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.689
4z9r FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.689
1kbq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.687
1ofe FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.687
1qcw FNSCytochrome b2, mitochondrial 1.1.2.3 0.687
1h7w FMNDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.686
2z9d FMNFMN-dependent NADH-azoreductase / 0.683
2b3d FADModulator of drug activity B / 0.680
1dxq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.676
1qbg FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.676
1djq FMNTrimethylamine dehydrogenase 1.5.8.2 0.675
3gr8 FMNNADPH dehydrogenase / 0.675
4j8p FMNFlavodoxin / 0.674
4qoe FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.674
4qof FMNRibosyldihydronicotinamide dehydrogenase [quinone] / 0.672
2gr3 FADFerredoxin reductase / 0.670
2q9u FMNA-type flavoprotein / 0.670
5a4k FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.670
3giy FMN(S)-mandelate dehydrogenase 1.1.99.31 0.665
1gox FMNPeroxisomal (S)-2-hydroxy-acid oxidase 1.1.3.15 0.664
1h69 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.663
3bw4 FMNPutative 2-nitropropane dioxygenase / 0.660
2c12 FADNitroalkane oxidase 1.7.3.1 0.659
3qfr FMNNADPH--cytochrome P450 reductase / 0.659
2iyg FMNAppA, antirepressor of ppsR, sensor of blue light / 0.656
4zvl FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.655
2gjn FMNNitronate monooxygenase 1.13.12.16 0.654
2pg0 FADAcyl-CoA dehydrogenase / 0.652
3esz FMNFlavodoxin / 0.651
2iyi FMNAppA, antirepressor of ppsR, sensor of blue light / 0.650
2vxa RBFDodecin / 0.650
5a89 FMNRiboflavin biosynthesis protein RibF 2.7.1.26 0.650