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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4at4 T6E BDNF/NT-3 growth factors receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4at4 T6EBDNF/NT-3 growth factors receptor 2.7.10.1 1.172
1ywn LIFVascular endothelial growth factor receptor 2 2.7.10.1 0.764
3wze BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.708
4asd BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.707
4equ G6ISerine/threonine-protein kinase 10 2.7.11.1 0.705
2og8 1N8Tyrosine-protein kinase Lck 2.7.10.2 0.686
2e2b 406Tyrosine-protein kinase ABL1 2.7.10.2 0.685
4tyj 0LIFibroblast growth factor receptor 4 2.7.10.1 0.685
3dko IHZEphrin type-A receptor 7 2.7.10.1 0.682
4agw NG7Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.679
3ugc 046Tyrosine-protein kinase JAK2 / 0.671
1uwh BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.665
3be2 RAJVascular endothelial growth factor receptor 2 2.7.10.1 0.662
3gcs BAXMitogen-activated protein kinase 14 / 0.661
2oh4 GIGVascular endothelial growth factor receptor 2 2.7.10.1 0.660
3nnx EDDMitogen-activated protein kinase 14 / 0.655
4uxq 0LIFibroblast growth factor receptor 4 2.7.10.1 0.655
2hiw 7MPTyrosine-protein kinase ABL1 2.7.10.2 0.654
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.652
4i5h G17Mitogen-activated protein kinase 1 2.7.11.24 0.651