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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4at2 ASD Possible succinate dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4at2 ASDPossible succinate dehydrogenase / 1.043
3uzz ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.720
1kdm DHTSex hormone-binding globulin / 0.708
3uzz TES3-oxo-5-beta-steroid 4-dehydrogenase / 0.704
1qyx ASDEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.703
4oed DHTAndrogen receptor / 0.703
1t7f DHTAndrogen receptor / 0.700
1t76 DHTAndrogen receptor / 0.699
2ylp TESAndrogen receptor / 0.699
1gwr ESTEstrogen receptor / 0.695
2q7i TESAndrogen receptor / 0.695
5dx3 ESTEstrogen receptor / 0.695
4pxm ESTEstrogen receptor / 0.688
2yhd TESAndrogen receptor / 0.687
3vhu SNLMineralocorticoid receptor / 0.687
3zqt TESAndrogen receptor / 0.683
1d2s DHTSex hormone-binding globulin / 0.680
2q7k TESAndrogen receptor / 0.680
4oez DHTAndrogen receptor / 0.679
1kdk DHTSex hormone-binding globulin / 0.677
2b03 TUDPhospholipase A2, major isoenzyme 3.1.1.4 0.677
3w5q 3KLVitamin D3 receptor / 0.677
2qpy DHTAndrogen receptor / 0.676
2ylo TESAndrogen receptor / 0.676
2ylq TESAndrogen receptor / 0.675
2z4j DHTAndrogen receptor / 0.673
3w5p 4OAVitamin D3 receptor / 0.673
4bb2 STRCorticosteroid-binding globulin / 0.673
1t5z DHTAndrogen receptor / 0.672
1lhw ESMSex hormone-binding globulin / 0.670
1gs4 ZK5Androgen receptor / 0.668
2pir DHTAndrogen receptor / 0.668
4ofu DHTAndrogen receptor / 0.667
4oea DHTAndrogen receptor / 0.666
4k7a DHTAndrogen receptor / 0.665
1lho AOMSex hormone-binding globulin / 0.664
3cmf PDN3-oxo-5-beta-steroid 4-dehydrogenase / 0.663
3w1w CHDFerrochelatase, mitochondrial 4.99.1.1 0.660
4ple CPSNuclear receptor subfamily 5 group A member 2 / 0.660
1t7m DHTAndrogen receptor / 0.659
3w5r LOAVitamin D3 receptor / 0.658
1t63 DHTAndrogen receptor / 0.657
2b1z 17MEstrogen receptor / 0.653
2q7j TESAndrogen receptor / 0.652
2q7l TESAndrogen receptor / 0.652
3dey DHTEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.652
3klm DHTEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.652
1xf0 ASDAldo-keto reductase family 1 member C3 / 0.651
2am9 TESAndrogen receptor / 0.650