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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4app N53 Serine/threonine-protein kinase PAK 4 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4app N53Serine/threonine-protein kinase PAK 4 2.7.11.1 1.132
2x4z X4ZSerine/threonine-protein kinase PAK 4 2.7.11.1 0.799
4ks7 X4ZSerine/threonine-protein kinase PAK 6 2.7.11.1 0.721
3fzs B96Protein-tyrosine kinase 2-beta 2.7.10.2 0.652