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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4aox FAD Steroid monooxygenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4aox FADSteroid monooxygenase / 1.264
4aos FADSteroid monooxygenase / 1.062
4ap3 FADSteroid monooxygenase / 1.009
4ap1 FADSteroid monooxygenase / 0.923
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.816
2eq7 FADDihydrolipoyl dehydrogenase / 0.799
2yqu FADDihydrolipoyl dehydrogenase / 0.766
2ylz FADPhenylacetone monooxygenase 1.14.13.92 0.765
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.761
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.759
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.758
4gut FADLysine-specific histone demethylase 1B 1 0.757
2eq6 FADDihydrolipoyl dehydrogenase / 0.755
4fwe FADLysine-specific histone demethylase 1B 1 0.754
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.743
2bry FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.739
2yg3 FADPutrescine oxidase / 0.739
4tlz FADKtzI / 0.739
2ylr FADPhenylacetone monooxygenase 1.14.13.92 0.738
2ym1 FADPhenylacetone monooxygenase 1.14.13.92 0.737
4mok FADPyranose 2-oxidase / 0.737
2ylt FADPhenylacetone monooxygenase 1.14.13.92 0.736
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.731
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.731
2ylw FADPhenylacetone monooxygenase 1.14.13.92 0.730
4gus FADLysine-specific histone demethylase 1B 1 0.728
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.728
3lsi FADPyranose 2-oxidase / 0.727
3mj4 FADUDP-galactopyranose mutase / 0.722
1ger FADGlutathione reductase 1.8.1.7 0.720
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.716
3up5 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.715
4jq9 FADDihydrolipoyl dehydrogenase / 0.714
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.712
3gwd FADCyclohexanone monooxygenase / 0.712
2q0l FADThioredoxin reductase 1.8.1.9 0.709
2tpr FADTrypanothione reductase 1.8.1.12 0.709
2ylx FADPhenylacetone monooxygenase 1.14.13.92 0.709
3gyj FADCholesterol oxidase 1.1.3.6 0.709
3ish FADThioredoxin reductase 1.8.1.9 0.709
3k30 ADPHistamine dehydrogenase / 0.708
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.707
2gv8 FADThiol-specific monooxygenase 1.14.13 0.707
3pl8 FADPyranose 2-oxidase / 0.707
2igo FADPyranose 2-oxidase / 0.706
4d03 FADPhenylacetone monooxygenase 1.14.13.92 0.706
4fwf FADLysine-specific histone demethylase 1B 1 0.706
1cbo FADCholesterol oxidase 1.1.3.6 0.705
2yg5 FADPutrescine oxidase / 0.705
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.705
4mih FADPyranose 2-oxidase 1.1.3.10 0.702
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.701
4txi FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.701
2eq8 FADDihydrolipoyl dehydrogenase / 0.700
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.699
2j3n FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.697
2yg4 FADPutrescine oxidase / 0.697
4xxg FADCholesterol oxidase 1.1.3.6 0.697
1w4x FADPhenylacetone monooxygenase 1.14.13.92 0.696
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.696
3k4c FADPyranose 2-oxidase / 0.696
5br7 FADUDP-galactopyranose mutase / 0.696
1n4v FADCholesterol oxidase 1.1.3.6 0.695
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.695
4cnk FADL-amino acid oxidase / 0.695
1b8s FADCholesterol oxidase 1.1.3.6 0.694
3kpk FADSulfide-quinone reductase / 0.694
1get FADGlutathione reductase 1.8.1.7 0.693
4b68 FADL-ornithine N(5)-monooxygenase / 0.692
4tm1 FDAKtzI / 0.692
4yac NAIC alpha-dehydrogenase / 0.692
2bra FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.691
2zbw FADFerredoxin--NADP reductase / 0.691
4u2s FDACholesterol oxidase 1.1.3.6 0.691
1h81 FADPolyamine oxidase 1.5.3.14 0.689
3lsh FADPyranose 2-oxidase / 0.689
3nlc FADUncharacterized protein / 0.689
1e1n FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.688
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.688
2yg7 FADPutrescine oxidase / 0.688
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.688
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.687
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.687
2r9z FADGlutathione amide reductase / 0.685
3g5s FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.685
2yls FADPhenylacetone monooxygenase 1.14.13.92 0.683
1y56 ATPUncharacterized protein / 0.682
2ign FADPyranose 2-oxidase / 0.682
4gde FDAUDP-galactopyranose mutase / 0.682
3alj FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.681
3m13 FADMonomeric sarcosine oxidase 1.5.3.1 0.681
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.681
1h6v FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.680
2q7v FADThioredoxin reductase / 0.680
3ad9 NADSubunit alpha of sarocosine oxidase / 0.680
3cnj FADCholesterol oxidase 1.1.3.6 0.680
4z24 FADPutative GMC-type oxidoreductase R135 1 0.680
2zz0 FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.679
4cnj FADL-amino acid oxidase / 0.679
4fwj FADLysine-specific histone demethylase 1B 1 0.679
4d04 FADPhenylacetone monooxygenase 1.14.13.92 0.678
2b9x FADPutative aminooxidase / 0.677
2jb2 FADL-amino acid oxidase / 0.677
2ym2 FADPhenylacetone monooxygenase 1.14.13.92 0.677
4rek FADCholesterol oxidase 1.1.3.6 0.677
2jae FADL-amino acid oxidase / 0.676
2jb1 FADL-amino acid oxidase / 0.676
2bac FADPutative aminooxidase / 0.675
3cnd FADPolyamine oxidase FMS1 / 0.675
3urh FADDihydrolipoyl dehydrogenase / 0.675
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.674
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.674
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.674
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.674
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.673
2gvc FADThiol-specific monooxygenase 1.14.13 0.673
4dna FADProbable glutathione reductase / 0.673
4k2x FADPolyketide oxygenase/hydroxylase / 0.673
2rgj FADFlavin-containing monooxygenase / 0.672
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.672
4gur FADLysine-specific histone demethylase 1B 1 0.672
1nhr FADNADH peroxidase 1.11.1.1 0.671
3l8k ADPDihydrolipoamide dehydrogenase (PdhD-3) / 0.671
5hsa FASAlcohol oxidase 1 1.1.3.13 0.671
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.670
1i8t FADUDP-galactopyranose mutase 5.4.99.9 0.670
3f8d FADNADH oxidase/thioredoxin reductase / 0.670
3s5w FADL-ornithine N(5)-monooxygenase / 0.670
2rab FADGlutathione amide reductase / 0.669
3dme FADPutative conserved exported protein / 0.669
3kpf FADPolyamine oxidase 1.5.3.14 0.669
1ijh FADCholesterol oxidase 1.1.3.6 0.668
2ba9 FADPutative aminooxidase / 0.668
2gew FADCholesterol oxidase 1.1.3.6 0.668
1ojt FADDihydrolipoyl dehydrogenase / 0.667
5cku FADL-ornithine N(5)-monooxygenase / 0.666
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.665
1nhq FADNADH peroxidase 1.11.1.1 0.665
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.665
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.665
4b64 FADL-ornithine N(5)-monooxygenase / 0.665
4gcm FADThioredoxin reductase 1.8.1.9 0.665
1lvl FADDihydrolipoyl dehydrogenase 1.8.1.4 0.664
2bab FADPutative aminooxidase / 0.664
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.664
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.664
3gd3 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.664
2cvj FADThioredoxin reductase related protein / 0.663
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.662
1npx FADNADH peroxidase 1.11.1.1 0.662
2ji7 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.662
1rsg FADPolyamine oxidase FMS1 / 0.661
1zmc NADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.661
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.661
3b6d FAECholesterol oxidase 1.1.3.6 0.661
3rha FDAPutrescine oxidase / 0.661
4tlx FDAKtzI / 0.661
3dgh FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.660
3int FDAUDP-galactopyranose mutase 5.4.99.9 0.660
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.660
1mxt FAECholesterol oxidase 1.1.3.6 0.659
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.659
4jnq FDAThioredoxin reductase / 0.659
1xpq FADPolyamine oxidase FMS1 / 0.658
2hqm FADGlutathione reductase 1.8.1.7 0.658
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.658
4b69 FADL-ornithine N(5)-monooxygenase / 0.658
4opl FDAConserved Archaeal protein / 0.658
4u2l SFDCholesterol oxidase 1.1.3.6 0.658
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.657
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.657
1y56 FAD382aa long hypothetical sarcosine oxidase / 0.657
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.657
4j56 FADThioredoxin reductase 2 1.8.1.9 0.657
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.656
2dw4 FADLysine-specific histone demethylase 1A 1 0.656
4tm4 FDAKtzI / 0.656
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.656
1cc2 FADCholesterol oxidase 1.1.3.6 0.655
1f8w FADNADH peroxidase 1.11.1.1 0.655
2b9w FADPutative aminooxidase / 0.655
2eq9 FADDihydrolipoyl dehydrogenase / 0.655
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.654
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.654
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.654
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.654
3ict FADCoenzyme A disulfide reductase / 0.654
3kkj FADRenalase / 0.654
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.653
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.653
3f8r NAPNADH oxidase/thioredoxin reductase / 0.653
4bk3 FADProbable salicylate monooxygenase / 0.653
4nwz FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.653
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.652
3lsm SFDPyranose 2-oxidase / 0.652
4u2t FADCholesterol oxidase 1.1.3.6 0.652
4xbf FADLysine-specific histone demethylase 1A 1 0.652
1gal FADGlucose oxidase 1.1.3.4 0.651
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.651
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.650
3gwf FADCyclohexanone monooxygenase / 0.650