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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4anb YQY Dual specificity mitogen-activated protein kinase kinase 1 2.7.12.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4anb YQYDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 1.320
4an2 EUIDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 1.004
4an9 2P7Dual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.920
3dv3 MEKDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.884
3v04 V04Dual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.864
2p55 MRADual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.857
4an3 5Y0Dual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.852
3vvh 4BMDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.824
3orn 3ORDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.819
3e8n VRADual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.793
4lmn EUIDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.777
3os3 3OSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.745
3dy7 1CXDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.731
3vs2 VSBTyrosine-protein kinase HCK 2.7.10.2 0.681