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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ajj 88R L-lactate dehydrogenase A chain 1.1.1.27

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ajj 88RL-lactate dehydrogenase A chain 1.1.1.27 1.172
4ajo 88NL-lactate dehydrogenase A chain 1.1.1.27 0.995
4ajp 88NL-lactate dehydrogenase A chain 1.1.1.27 0.978
4ajn 88VL-lactate dehydrogenase A chain 1.1.1.27 0.926
4i8x 6P3L-lactate dehydrogenase A chain 1.1.1.27 0.665
1ex7 5GPGuanylate kinase 2.7.4.8 0.655
2w5a ADPSerine/threonine-protein kinase Nek2 2.7.11.1 0.654
4gte FADFlavin-dependent thymidylate synthase 2.1.1.148 0.652
1h8h ADPATP synthase subunit alpha, mitochondrial / 0.651
1h8h ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.651
2wzm NA7Uncharacterized oxidoreductase MSMEG_2407/MSMEI_2346 / 0.650