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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4agu D15 Cyclin-dependent kinase-like 1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4agu D15Cyclin-dependent kinase-like 1 / 1.097
2jds L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.760
4e5i 0N9Polymerase acidic protein / 0.744
2jdv L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.730
3l9m L9McAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.713
3ezv EZVCyclin-dependent kinase 2 2.7.11.22 0.693
3l9n L9NcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.693
2uzu L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.691
1vyw 292Cyclin-dependent kinase 2 2.7.11.22 0.690
2f7e 2EAcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
4fkj 11KCyclin-dependent kinase 2 2.7.11.22 0.679
1rej B1LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.678
3nun JMZ3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.676
2vti LZ3Cyclin-dependent kinase 2 2.7.11.22 0.675
3v8s 0HDRho-associated protein kinase 1 2.7.11.1 0.675
4fki 09KCyclin-dependent kinase 2 2.7.11.22 0.674
4bgq 38RCyclin-dependent kinase-like 5 2.7.11.22 0.665
4ek6 10KCyclin-dependent kinase 2 2.7.11.22 0.662
4mm4 8PRNa(+):neurotransmitter symporter (Snf family) / 0.662
1vyz N5BCyclin-dependent kinase 2 2.7.11.22 0.660
2c1a I5ScAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
1gii 1PUCyclin-dependent kinase 2 2.7.11.22 0.652
2hy8 1STSerine/threonine-protein kinase PAK 1 2.7.11.1 0.650