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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4af3 VX6 Aurora kinase B 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4af3 VX6Aurora kinase B 2.7.11.1 1.081
3e5a VX6Aurora kinase A 2.7.11.1 0.787
2f4j VX6Tyrosine-protein kinase ABL1 2.7.10.2 0.731
4jbq VX6Aurora kinase A 2.7.11.1 0.726
3amb VX6cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.720
2xyn VX6Abelson tyrosine-protein kinase 2 2.7.10.2 0.690
4b8m VX6Aurora kinase B-A 2.7.11.1 0.674
1y6a AAZVascular endothelial growth factor receptor 2 2.7.10.1 0.664
2xa4 AZ5Tyrosine-protein kinase JAK2 / 0.663
3w16 P9JAurora kinase A 2.7.11.1 0.662
4e5f 0N7Polymerase acidic protein / 0.660
3w10 RO9Aurora kinase A 2.7.11.1 0.654