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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3zky WT4 Isopenicillin N synthase 1.21.3.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3zky WT4Isopenicillin N synthase 1.21.3.1 1.012
2vcm M11Isopenicillin N synthase 1.21.3.1 0.785
2bjs ACVIsopenicillin N synthase 1.21.3.1 0.746
1hb3 SCVIsopenicillin N synthase 1.21.3.1 0.741
1odn APVIsopenicillin N synthase 1.21.3.1 0.741
1qiq ACCIsopenicillin N synthase 1.21.3.1 0.715
1oc1 ASVIsopenicillin N synthase 1.21.3.1 0.711
2wo7 ASVIsopenicillin N synthase 1.21.3.1 0.706
2y60 M8FIsopenicillin N synthase 1.21.3.1 0.694
3zoi M2WIsopenicillin N synthase 1.21.3.1 0.693
1blz ACVIsopenicillin N synthase 1.21.3.1 0.678
2jb4 A14Isopenicillin N synthase 1.21.3.1 0.673
2tpl HPPTyrosine phenol-lyase 4.1.99.2 0.669
4ajn 88VL-lactate dehydrogenase A chain 1.1.1.27 0.665
1hb1 OCVIsopenicillin N synthase 1.21.3.1 0.664
1w06 W05Isopenicillin N synthase 1.21.3.1 0.664
1u4s BIHL-lactate dehydrogenase 1.1.1.27 0.662
4dld TZGGlutamate receptor ionotropic, kainate 1 / 0.662
1uzw CDHIsopenicillin N synthase 1.21.3.1 0.654
2vbp VB1Isopenicillin N synthase 1.21.3.1 0.654
3lnc 5GPGuanylate kinase / 0.654
1qjf ACSIsopenicillin N synthase 1.21.3.1 0.652
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.650
1tdr MTXDihydrofolate reductase 1.5.1.3 0.650