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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3w6h AZM Carbonic anhydrase 1 4.2.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3w6h AZMCarbonic anhydrase 1 4.2.1.1 0.808
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1jsz NDMCap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2.1.1.57 0.744
1v2h GUNPurine nucleoside phosphorylase 2.4.2.1 0.744
1efz PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.726
3e67 H4BNitric oxide synthase, inducible 1.14.13.39 0.710
1p0e PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.706
2pot GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.702
4uga H4BNitric oxide synthase oxygenase 1.14.13.165 0.693
4ug7 H4BNitric oxide synthase oxygenase 1.14.13.165 0.691
1m8d H4BNitric oxide synthase, inducible 1.14.13.39 0.689
2fr8 NADNAD(P) transhydrogenase subunit alpha part 1 1.6.1.2 0.688
3ict ADPCoenzyme A disulfide reductase / 0.688
4ykl GMPAprataxin-like protein 3 0.688
1r5y DQUQueuine tRNA-ribosyltransferase 2.4.2.29 0.686
2vcz VC3Hematopoietic prostaglandin D synthase / 0.686
3blo QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.684
1jpa ANPEphrin type-B receptor 2 2.7.10.1 0.678
2nod H4BNitric oxide synthase, inducible 1.14.13.39 0.677
1m8i H4BNitric oxide synthase, inducible 1.14.13.39 0.675
4dtb GMPAPH(2'')-Id / 0.675
2wmv ZYVSerine/threonine-protein kinase Chk1 2.7.11.1 0.673
3e6o H4BNitric oxide synthase, inducible 1.14.13.39 0.673
4dt8 ADNAPH(2'')-Id / 0.672
4s34 ANPMitogen-activated protein kinase 1 2.7.11.24 0.672
4js9 H4BNitric oxide synthase, inducible 1.14.13.39 0.670
2ydi YDISerine/threonine-protein kinase Chk1 2.7.11.1 0.668
3o0q ADNVitamin B12-dependent ribonucleotide reductase / 0.668
3eah 327Nitric oxide synthase, endothelial 1.14.13.39 0.667
2eg2 ATPNitrogen regulatory protein P-II / 0.665
2x9n AX3Pteridine reductase / 0.665
3pb5 F63Endothiapepsin 3.4.23.22 0.665
4pgh SAMCaffeic acid O-methyltransferase / 0.665
4zob LGCLin1840 protein / 0.662
1i7c MGBS-adenosylmethionine decarboxylase proenzyme 4.1.1.50 0.660
1ozq PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2ofi ADK3-methyladenine DNA glycosylase I / 0.660
2pwu GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2z1x PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
3bld PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
3fro NHFGlgA glycogen synthase / 0.660
4gcx PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4h7z GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hqv QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hvx QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1p6j DP9Nitric oxide synthase, brain 1.14.13.39 0.657
3h2c B58Dihydropteroate synthase / 0.657
4b0j 3MQ3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase 4.2.1.59 0.657
1y5v NE8Queuine tRNA-ribosyltransferase 2.4.2.29 0.656
3djf BC3Purine nucleoside phosphorylase / 0.656
1u2y GOXPancreatic alpha-amylase / 0.655
1dwx H4BNitric oxide synthase, inducible 1.14.13.39 0.654
1yum NCNProbable nicotinate-nucleotide adenylyltransferase 2.7.7.18 0.654
2pzr ACPFibroblast growth factor receptor 2 / 0.654
4bdd Z0OSerine/threonine-protein kinase Chk2 2.7.11.1 0.654
5cfn 2BAStimulator of interferon genes protein / 0.653
4iq7 1G9Mycocyclosin synthase 1.14.21.9 0.652
4uov AZMCarbonate dehydratase / 0.652
4f1t H52Probable serine/threonine-protein kinase roco4 2.7.11.1 0.651
2ydk YDKSerine/threonine-protein kinase Chk1 2.7.11.1 0.650
4bda VFBSerine/threonine-protein kinase Chk2 2.7.11.1 0.650