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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3w5q 3KL Vitamin D3 receptor

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3w5q 3KLVitamin D3 receptor / 1.317
3w5p 4OAVitamin D3 receptor / 1.272
3w5r LOAVitamin D3 receptor / 1.119
4q0a 4OAVitamin D3 receptor A / 1.103
3w5t LHPVitamin D3 receptor / 1.056
2b04 CHOPhospholipase A2, major isoenzyme 3.1.1.4 0.727
2jn3 JN3Fatty acid-binding protein, liver / 0.724
3up3 XCAaceDAF-12 / 0.716
1sqn NDRProgesterone receptor / 0.710
1xu7 CPSCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.710
1xu9 CPSCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.709
3f3y 4OABile salt sulfotransferase 2.8.2.14 0.705
4ple CPSNuclear receptor subfamily 5 group A member 2 / 0.700
2q7k TESAndrogen receptor / 0.694
2qd4 CHDFerrochelatase, mitochondrial 4.99.1.1 0.693
2azz TCHPhospholipase A2, major isoenzyme 3.1.1.4 0.692
3uud ESTEstrogen receptor / 0.692
4ofr DHTAndrogen receptor / 0.689
1t63 DHTAndrogen receptor / 0.685
2aa6 STRMineralocorticoid receptor / 0.685
3nhx ASDSteroid Delta-isomerase 5.3.3.1 0.685
1g50 ESTEstrogen receptor / 0.682
2pnu ENMAndrogen receptor / 0.681
1jtv TESEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.680
2q7i TESAndrogen receptor / 0.680
4at2 ASDPossible succinate dehydrogenase / 0.677
1t7r DHTAndrogen receptor / 0.674
1gwr ESTEstrogen receptor / 0.673
4oed DHTAndrogen receptor / 0.673
3cot STR3-oxo-5-beta-steroid 4-dehydrogenase / 0.669
4c49 HCYCorticosteroid-binding globulin / 0.665
1qyx ASDEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.664
1i5r HYCEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.663
2b03 TUDPhospholipase A2, major isoenzyme 3.1.1.4 0.662
2qo5 CHDFatty acid-binding protein 10-A, liver basic / 0.662
5hyr ESTEstrogen receptor / 0.661
2pio DHTAndrogen receptor / 0.660
2aba STRPentaerythritol tetranitrate reductase / 0.659
2ocf ESTEstrogen receptor / 0.658
4bqu CLRJapanin / 0.656
2k62 ITLFatty acid-binding protein, liver / 0.655
3lfa 1N1Mitogen-activated protein kinase 14 / 0.655
4y8w STRSteroid 21-hydroxylase / 0.655
1m2z DEXGlucocorticoid receptor / 0.654
3w1w CHDFerrochelatase, mitochondrial 4.99.1.1 0.654
3uzx AOX3-oxo-5-beta-steroid 4-dehydrogenase / 0.653
2j7x ESTEstrogen receptor beta / 0.650
3iw1 ASDSteroid C26-monooxygenase 1.14.13.141 0.650