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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3w2e FAD NADH-cytochrome b5 reductase 3 1.6.2.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3w2e FADNADH-cytochrome b5 reductase 3 1.6.2.2 1.428
3w2f FADNADH-cytochrome b5 reductase 3 1.6.2.2 1.343
4wqm FADToluene-4-monooxygenase electron transfer component 1.18.1.3 1.050
1ja1 FADNADPH--cytochrome P450 reductase / 1.019
3fpk FADFerredoxin-NADP reductase / 1.002
1krh FADBenzoate 1,2-dioxygenase electron transfer component 1.18.1.3 1.000
1umk FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.997
3qfs FADNADPH--cytochrome P450 reductase / 0.983
3w5h FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.982
1cqx FADFlavohemoprotein / 0.978
4y9r FADNADPH--cytochrome P450 reductase / 0.964
4y7c FADNADPH--cytochrome P450 reductase / 0.958
3qfr FADNADPH--cytochrome P450 reductase / 0.955
3ojw FADNADPH--cytochrome P450 reductase / 0.953
3ojx FADNADPH--cytochrome P450 reductase / 0.940
4y9u FADNADPH--cytochrome P450 reductase / 0.925
1amo FADNADPH--cytochrome P450 reductase / 0.921
3qfc FADNADPH--cytochrome P450 reductase / 0.919
1qh0 FADFerredoxin--NADP reductase 1.18.1.2 0.916
1fnc FDAFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.905
4yau FADNADPH--cytochrome P450 reductase / 0.903
1sm4 FADFerredoxin--NADP reductase / 0.902
4yaf FADNADPH--cytochrome P450 reductase / 0.878
4c43 FADFerredoxin--NADP reductase 1.18.1.2 0.876
1i7p FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.872
3w5u FADFerredoxin / 0.871
1j9z FADNADPH--cytochrome P450 reductase / 0.868
1qg0 FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic 1.18.1.2 0.868
1fdr FADFerredoxin--NADP reductase 1.18.1.2 0.866
2vnj FADNADPH:ferredoxin reductase / 0.866
1e64 FADFerredoxin--NADP reductase 1.18.1.2 0.865
3mhp FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic 1.18.1.2 0.864
1e62 FADFerredoxin--NADP reductase 1.18.1.2 0.862
1e63 FADFerredoxin--NADP reductase 1.18.1.2 0.861
1f20 FADNitric oxide synthase, brain 1.14.13.39 0.860
4fk8 FADFerredoxin--NADP reductase / 0.860
1bx1 FADFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.850
1que FADFerredoxin--NADP reductase 1.18.1.2 0.849
3qft FADNADPH--cytochrome P450 reductase / 0.848
4bpr FADFerredoxin--NADP reductase 1.18.1.2 0.847
2vyq FADFerredoxin--NADP reductase 1.18.1.2 0.840
1fnd FADFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.836
1fnb FADFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.833
2vnh FADNADPH:ferredoxin reductase / 0.833
1ndh FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.831
1tll FADNitric oxide synthase, brain 1.14.13.39 0.829
2eix FADNADH-cytochrome b5 reductase / 0.825
4af7 FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic 1.18.1.2 0.825
3qe2 FADNADPH--cytochrome P450 reductase / 0.814
2bf4 FADNADPH--cytochrome P450 reductase / 0.813
2bgi FADNADPH:ferredoxin reductase / 0.810
2qdx FADFerredoxin--NADP+ reductase / 0.810
1w35 FADFerredoxin--NADP reductase 1.18.1.2 0.809
1w34 FADFerredoxin--NADP reductase 1.18.1.2 0.808
1ja0 FADNADPH--cytochrome P450 reductase / 0.804
2vnk FADNADPH:ferredoxin reductase / 0.803
2bgj FADNADPH:ferredoxin reductase / 0.802
4yao FADNADPH--cytochrome P450 reductase / 0.791
1bx0 FADFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.785
3crz FADFerredoxin--NADP+ reductase / 0.782
2bn4 FADNADPH--cytochrome P450 reductase / 0.778
2b5o FADFerredoxin--NADP reductase 1.18.1.2 0.777
2rc5 FADFerredoxin--NADP reductase / 0.777
1gvh FADFlavohemoprotein / 0.776
2bpo FADNADPH--cytochrome P450 reductase / 0.773
1go2 FADFerredoxin--NADP reductase 1.18.1.2 0.771
1gr1 FADFerredoxin--NADP reductase 1.18.1.2 0.771
1qgy FADFerredoxin--NADP reductase 1.18.1.2 0.771
3zbt FADFerredoxin--NADP reductase 1.18.1.2 0.770
2r6h FADNa(+)-translocating NADH-quinone reductase subunit F / 0.768
4af6 FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic 1.18.1.2 0.764
2ok7 FADFerredoxin--NADP reductase, apicoplast / 0.760
1w87 FADFerredoxin--NADP reductase 1.18.1.2 0.758
1b2r FADFerredoxin--NADP reductase 1.18.1.2 0.756
1ogi FADFerredoxin--NADP reductase 1.18.1.2 0.755
4b4d FADFerredoxin-NADP reductase / 0.755
1bjk FADFerredoxin--NADP reductase 1.18.1.2 0.752
1h85 FADFerredoxin--NADP reductase 1.18.1.2 0.752
3zc3 FADFerredoxin--NADP reductase 1.18.1.2 0.751
1gaq FADFerredoxin / 0.745
3in6 FMNUncharacterized protein / 0.745
1gjr FADFerredoxin--NADP reductase 1.18.1.2 0.740
1h42 FADFerredoxin--NADP reductase 1.18.1.2 0.739
1qgz FADFerredoxin--NADP reductase 1.18.1.2 0.738
1ib0 FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.735
1ogj FADFerredoxin--NADP reductase 1.18.1.2 0.732
1a8p FADFerredoxin--NADP reductase / 0.730
2cnd FADNitrate reductase [NADH] 1.7.1.1 0.730
3vo2 FADFerredoxin--NADP reductase / 0.728
3jqr FADFerredoxin--NADP reductase, apicoplast / 0.719
1gaw FADFerredoxin / 0.717
2gpj FADSiderophore-interacting protein / 0.717
1usc FMNMonooxygenase / 0.716
2i51 FMNPyridoxamine 5'-phosphate oxidase-related, FMN-binding / 0.706
2igo FADPyranose 2-oxidase / 0.703
2ok8 FADFerredoxin--NADP reductase, apicoplast / 0.703
3e4v FMNUncharacterized protein / 0.702
4uaj FADNa(+)-translocating NADH-quinone reductase subunit F / 0.702
1cnf FADNitrate reductase [NADH] 1.7.1.1 0.694
2xnc FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic 1.18.1.2 0.690
1eje FMNProtein MTH_152 / 0.689
2pia FMNPhthalate dioxygenase reductase / 0.689
2rc6 FADFerredoxin--NADP reductase / 0.689
4ylf FADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit homolog / 0.689
5cho FADFlavin reductase / 0.685
3vy2 FMNFMN-binding protein / 0.684
1pkv RBFRiboflavin synthase 2.5.1.9 0.681
4k1x FADNADPH:ferredoxin reductase / 0.679
2pr5 FMNBlue-light photoreceptor / 0.677
2nr4 FMNConserved protein / 0.674
3bnk FMNFlavoredoxin / 0.674
1ep3 FADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit / 0.673
1i0s FMNFerric-chelate reductase (NAD(P)H) / 0.672
1kqb FMNOxygen-insensitive NAD(P)H nitroreductase / 0.669
1oon FMNOxygen-insensitive NAD(P)H nitroreductase / 0.668
1icu FMNOxygen-insensitive NAD(P)H nitroreductase / 0.667
1kqc FMNOxygen-insensitive NAD(P)H nitroreductase / 0.667
1kqd FMNOxygen-insensitive NAD(P)H nitroreductase / 0.667
1ty9 FMNPhenazine biosynthesis protein PhzG 1.4 0.667
1n07 FMNRiboflavin kinase 2.7.1.26 0.662
2hq9 FADMll6688 protein / 0.662
3a6q FMNFMN-binding protein / 0.659
3a6r FMNFMN-binding protein / 0.659
1icv FMNOxygen-insensitive NAD(P)H nitroreductase / 0.657
1ooq FMNOxygen-insensitive NAD(P)H nitroreductase / 0.656
1gzf NADMono-ADP-ribosyltransferase C3 2.4.2 0.654
4fwe FADLysine-specific histone demethylase 1B 1 0.652
1rz0 FADPhenol 2-hydroxylase component B / 0.651