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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3w16 P9J Aurora kinase A 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3w16 P9JAurora kinase A 2.7.11.1 0.873
3w10 RO9Aurora kinase A 2.7.11.1 0.757
4e5i 0N9Polymerase acidic protein / 0.744
4nka 2K7Fibroblast growth factor receptor 1 / 0.722
4jbq VX6Aurora kinase A 2.7.11.1 0.717
4c61 LMMTyrosine-protein kinase JAK2 / 0.709
4f65 0S9Fibroblast growth factor receptor 1 / 0.704
3e5a VX6Aurora kinase A 2.7.11.1 0.703
2xa4 AZ5Tyrosine-protein kinase JAK2 / 0.702
4f64 0S8Fibroblast growth factor receptor 1 / 0.700
4b8m VX6Aurora kinase B-A 2.7.11.1 0.698
4f63 0S7Fibroblast growth factor receptor 1 / 0.694
3ggf GVDSerine/threonine-protein kinase 26 / 0.690
3nlb 5BESerine/threonine-protein kinase Chk1 2.7.11.1 0.689
4fkg 4CKCyclin-dependent kinase 2 2.7.11.22 0.684
4nk9 2K5Fibroblast growth factor receptor 1 / 0.684
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.683
4bdh WVISerine/threonine-protein kinase Chk2 2.7.11.1 0.682
4fkj 11KCyclin-dependent kinase 2 2.7.11.22 0.681
1vyw 292Cyclin-dependent kinase 2 2.7.11.22 0.679
4ek6 10KCyclin-dependent kinase 2 2.7.11.22 0.679
1vyz N5BCyclin-dependent kinase 2 2.7.11.22 0.678
4fki 09KCyclin-dependent kinase 2 2.7.11.22 0.671
2bmc MPYAurora kinase A 2.7.11.1 0.670
3qcy 3Q33-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.670
3nun JMZ3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.668
3amb VX6cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.667
1oec AA2Fibroblast growth factor receptor 2 / 0.666
3lfq A28Cyclin-dependent kinase 2 2.7.11.22 0.665
3tkh 07SSerine/threonine-protein kinase Chk1 2.7.11.1 0.665
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.663
3zly YSODual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.663
1zlt HYMSerine/threonine-protein kinase Chk1 2.7.11.1 0.662
2qhn 582Serine/threonine-protein kinase Chk1 2.7.11.1 0.662
4af3 VX6Aurora kinase B 2.7.11.1 0.662
4agc AXIVascular endothelial growth factor receptor 2 2.7.10.1 0.662
3qcq 3Q03-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.660
3qcx 3Q23-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.660
4e20 0MYNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.660
4e5f 0N7Polymerase acidic protein / 0.660
3lfs A07Cyclin-dependent kinase 2 2.7.11.22 0.659
2gdo 12CSerine/threonine-protein kinase Chk1 2.7.11.1 0.657
2x4z X4ZSerine/threonine-protein kinase PAK 4 2.7.11.1 0.657
2xng A0HAurora kinase A 2.7.11.1 0.657
2j50 627Aurora kinase A 2.7.11.1 0.656
2bro DF2Serine/threonine-protein kinase Chk1 2.7.11.1 0.655
3tki S25Serine/threonine-protein kinase Chk1 2.7.11.1 0.655
2jc6 QPPCalcium/calmodulin-dependent protein kinase type 1D 2.7.11.17 0.654
4o0r X4ZSerine/threonine-protein kinase PAK 1 2.7.11.1 0.654
4fsm HK1Serine/threonine-protein kinase Chk1 2.7.11.1 0.651
2vn9 GVDCalcium/calmodulin-dependent protein kinase type II subunit delta 2.7.11.17 0.650
4bdf H3RSerine/threonine-protein kinase Chk2 2.7.11.1 0.650