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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3vry B43 Tyrosine-protein kinase HCK 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3vry B43Tyrosine-protein kinase HCK 2.7.10.2 1.111
3vs3 VSETyrosine-protein kinase HCK 2.7.10.2 1.003
3vs4 VSFTyrosine-protein kinase HCK 2.7.10.2 0.995
1qcf PP1Tyrosine-protein kinase HCK 2.7.10.2 0.853
3vs5 VSGTyrosine-protein kinase HCK 2.7.10.2 0.851
2c0i L1GTyrosine-protein kinase HCK 2.7.10.2 0.819
2c0t L3GTyrosine-protein kinase HCK 2.7.10.2 0.809
2c0o L2GTyrosine-protein kinase HCK 2.7.10.2 0.791
1yol S03Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.761
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3vrz VRZTyrosine-protein kinase HCK 2.7.10.2 0.736
3vs1 VSATyrosine-protein kinase HCK 2.7.10.2 0.713
2zv9 PP2Tyrosine-protein kinase Lyn 2.7.10.2 0.707
4mxa BK7Calmodulin-like domain protein kinase isoenzyme gamma, related / 0.699
4d9t 0JGRibosomal protein S6 kinase alpha-3 2.7.11.1 0.698
3vs7 KS1Tyrosine-protein kinase HCK 2.7.10.2 0.697
4rw6 494Gag-Pol polyprotein 2.7.7.49 0.683
3vs0 VS0Tyrosine-protein kinase HCK 2.7.10.2 0.677
5ar4 SB2Receptor-interacting serine/threonine-protein kinase 2 2.7.11.1 0.670
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.661
4dgg I76Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.661
1qpe PP2Tyrosine-protein kinase Lck 2.7.10.2 0.660
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.659
3bhm AB3Carbonyl reductase [NADPH] 1 1.1.1.184 0.659
3w2s W2REpidermal growth factor receptor 2.7.10.1 0.653