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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3vjo ANP Epidermal growth factor receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.813
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.773
2itn ANPEpidermal growth factor receptor 2.7.10.1 0.733
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.729
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.715
4dt8 ADNAPH(2'')-Id / 0.709
4wzy ATPMaltokinase 2.7.1.175 0.701
2gs7 ANPEpidermal growth factor receptor 2.7.10.1 0.697
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.693
5cno ANPEpidermal growth factor receptor 2.7.10.1 0.689
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.687
4fl3 ANPTyrosine-protein kinase SYK 2.7.10.2 0.686
4gva ADPMitogen-activated protein kinase 1 2.7.11.24 0.686
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.684
5cnn ANPEpidermal growth factor receptor 2.7.10.1 0.684
2pml ANPUncharacterized protein / 0.683
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.683
4xhg ADPUncharacterized protein / 0.683
3ac1 KZITyrosine-protein kinase Lck 2.7.10.2 0.682
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.682
4k2r ANPTyrosine-protein kinase ZAP-70 2.7.10.2 0.682
3lij ANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands / 0.679
4gt3 ATPMitogen-activated protein kinase 1 2.7.11.24 0.679
1wbp ADPSRSF protein kinase 1 2.7.11.1 0.677
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.676
1wpg ADPSarcoplasmic/endoplasmic reticulum calcium ATPase 1 3.6.3.8 0.674
2eb3 ANPEpidermal growth factor receptor 2.7.10.1 0.674
1jpa ANPEphrin type-B receptor 2 2.7.10.1 0.673
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.673
2itx ANPEpidermal growth factor receptor 2.7.10.1 0.673
2pul ACPMethylthioribose kinase 2.7.1.100 0.673
4fic 0ULProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.673
1e1v CMGCyclin-dependent kinase 2 2.7.11.22 0.672
2olc ADPMethylthioribose kinase 2.7.1.100 0.672
2vcz VC3Hematopoietic prostaglandin D synthase / 0.671
3b2t M33Fibroblast growth factor receptor 2 / 0.671
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.670
4m15 ADPTyrosine-protein kinase ITK/TSK 2.7.10.2 0.670
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.668
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.667
4nm0 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.667
4bix ADPSensor histidine kinase CpxA / 0.666
2opn SUFFarnesyl pyrophosphate synthase 2.5.1.10 0.665
3pxk PXKFocal adhesion kinase 1 2.7.10.2 0.665
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.665
5ckw ANPUncharacterized protein / 0.665
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.664
3akl ANPSerine/threonine-protein kinase CtkA 2.7.11.1 0.664
2pzr ACPFibroblast growth factor receptor 2 / 0.663
1ztf XYARIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.662
2pui ADPMethylthioribose kinase 2.7.1.100 0.662
3blq ATPCyclin-dependent kinase 9 2.7.11.22 0.662
3q5i ANPProtein kinase, putative / 0.662
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.661
4oac ADPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.661
3ac2 KSETyrosine-protein kinase Lck 2.7.10.2 0.659
3t8o ATPRhodopsin kinase / 0.659
4egi B2JHeat shock protein HSP 90-alpha / 0.659
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.659
4xx9 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.659
1amw ADPATP-dependent molecular chaperone HSP82 / 0.658
4gu9 4GUFocal adhesion kinase 1 2.7.10.2 0.658
4rqk ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.656
4uya AGSMitogen-activated protein kinase kinase kinase 21 2.7.11.25 0.656
3p23 ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.655
4f1m ACPProbable serine/threonine-protein kinase roco4 2.7.11.1 0.655
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.655
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.654
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.654
2w5b AGSSerine/threonine-protein kinase Nek2 2.7.11.1 0.654
2wi2 ZZ3Heat shock protein HSP 90-alpha / 0.654
1fq1 ATPCyclin-dependent kinase 2 2.7.11.22 0.653
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.653
1h1p CMGCyclin-dependent kinase 2 2.7.11.22 0.652
1jst ATPCyclin-dependent kinase 2 2.7.11.22 0.652
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.652
1u54 ACPActivated CDC42 kinase 1 / 0.652
2uze C95Cyclin-dependent kinase 2 2.7.11.22 0.652
2yee 2ECHeat shock protein HSP 90-alpha / 0.652
2zoq 5IDMitogen-activated protein kinase 3 2.7.11.24 0.652
3c50 ADPRhodopsin kinase / 0.652
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
4aw0 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.652
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.652
2ydi YDISerine/threonine-protein kinase Chk1 2.7.11.1 0.651
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.651
2qoc ANPEphrin type-A receptor 3 2.7.10.1 0.650
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.650
2weg FBVCarbonic anhydrase 2 4.2.1.1 0.650
3ffp LC1Carbonic anhydrase 2 4.2.1.1 0.650
4avl TMPPolymerase acidic protein / 0.650
4blt APCNTPase P4 / 0.650
4c2w ANPAurora kinase B-A 2.7.11.1 0.650
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.650