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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3v5j 0F2 Tyrosine-protein kinase ITK/TSK 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3v5j 0F2Tyrosine-protein kinase ITK/TSK 2.7.10.2 0.850
3v8t 477Tyrosine-protein kinase ITK/TSK 2.7.10.2 0.767
3v8w 0G2Tyrosine-protein kinase ITK/TSK 2.7.10.2 0.753
3v5l 0G1Tyrosine-protein kinase ITK/TSK 2.7.10.2 0.720
3vf9 477Tyrosine-protein kinase SYK 2.7.10.2 0.682
4e5f 0N7Polymerase acidic protein / 0.660
2w1g L0GAurora kinase A 2.7.11.1 0.653
3vf8 0JETyrosine-protein kinase SYK 2.7.10.2 0.652
2vtt LZDCyclin-dependent kinase 2 2.7.11.22 0.651