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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3uud EST Estrogen receptor

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3uud ESTEstrogen receptor / 1.194
5dxg ESTEstrogen receptor / 1.170
4pxm ESTEstrogen receptor / 1.130
2yja ESTEstrogen receptor / 1.128
2qgt EEDEstrogen receptor / 1.106
5hyr ESTEstrogen receptor / 1.100
3l03 4OHEstrogen receptor / 1.069
1gwr ESTEstrogen receptor / 1.065
2p15 EZTEstrogen receptor / 1.048
3q95 ESLEstrogen receptor / 1.046
5dx3 ESTEstrogen receptor / 1.039
2b1z 17MEstrogen receptor / 1.018
2j7x ESTEstrogen receptor beta / 1.013
3oll ESTEstrogen receptor beta / 1.010
4j24 ESTEstrogen receptor beta / 0.984
2yat EEUEstrogen receptor / 0.970
2g5o DRQEstrogen receptor / 0.962
2ocf ESTEstrogen receptor / 0.937
1g50 ESTEstrogen receptor / 0.910
1x7e 244Estrogen receptor / 0.770
2qa8 GENEstrogen receptor / 0.770
2pog WSTEstrogen receptor / 0.747
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4iui 1GQEstrogen receptor / 0.744
1lhu ESTSex hormone-binding globulin / 0.727
1i5r HYCEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.725
2fai 459Estrogen receptor / 0.725
3gki CLRNiemann-Pick C1 protein / 0.725
2w8y 486Progesterone receptor / 0.706
1x7r GENEstrogen receptor / 0.696
1lhw ESMSex hormone-binding globulin / 0.695
3w5q 3KLVitamin D3 receptor / 0.692
2ao6 R18Androgen receptor / 0.682
4bqu CLRJapanin / 0.679
3cas ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.677
3cot STR3-oxo-5-beta-steroid 4-dehydrogenase / 0.673
1xf0 ASDAldo-keto reductase family 1 member C3 / 0.672
4q0a 4OAVitamin D3 receptor A / 0.672
1fdu ESTEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.671
3bej MUFBile acid receptor / 0.671
4j26 ESTEstrogen receptor beta / 0.670
1sqn NDRProgesterone receptor / 0.668
4ofr DHTAndrogen receptor / 0.668
3gyu DL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily / 0.665
4hlw TESAndrogen receptor / 0.665
1aqu ESTEstrogen sulfotransferase, testis isoform 2.8.2.4 0.664
2jn3 JN3Fatty acid-binding protein, liver / 0.664
3w5p 4OAVitamin D3 receptor / 0.664
2aa7 1CAMineralocorticoid receptor / 0.663
1gwq ZTWEstrogen receptor / 0.662
3up0 D7SaceDAF-12 / 0.662
3bur TES3-oxo-5-beta-steroid 4-dehydrogenase / 0.661
3uzx AOX3-oxo-5-beta-steroid 4-dehydrogenase / 0.661
4e5f 0N7Polymerase acidic protein / 0.660
3uzx AOM3-oxo-5-beta-steroid 4-dehydrogenase / 0.657
2aa5 STRMineralocorticoid receptor / 0.656
4dma 0L8Estrogen receptor / 0.655
3d90 NOGProgesterone receptor / 0.654
4j6d TESCytochrome P450 monooxygenase / 0.653
1err RALEstrogen receptor / 0.652
3i68 J4ZDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.652
4e5l DBHPolymerase acidic protein / 0.652
4nky 3QZSteroid 17-alpha-hydroxylase/17,20 lyase / 0.652
1ya3 STRMineralocorticoid receptor / 0.651