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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3uox FAD 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 1.387
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 1.306
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 1.149
3up5 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 1.030
3uoz FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 1.014
3gwf FADCyclohexanone monooxygenase / 0.998
3up4 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.988
3gwd FADCyclohexanone monooxygenase / 0.924
2ylx FADPhenylacetone monooxygenase 1.14.13.92 0.875
1w4x FADPhenylacetone monooxygenase 1.14.13.92 0.874
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.846
4gcm FADThioredoxin reductase 1.8.1.9 0.824
2ylz FADPhenylacetone monooxygenase 1.14.13.92 0.820
3cgc FADCoenzyme A disulfide reductase / 0.808
4aos FADSteroid monooxygenase / 0.808
4d04 FADPhenylacetone monooxygenase 1.14.13.92 0.805
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.804
4ap3 FADSteroid monooxygenase / 0.803
4nzh FADL-ornithine N(5)-monooxygenase / 0.790
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.789
2ym2 FADPhenylacetone monooxygenase 1.14.13.92 0.788
4ap1 FADSteroid monooxygenase / 0.785
2q7v FADThioredoxin reductase / 0.777
2yg6 FADPutrescine oxidase / 0.768
2xve FADPutative flavin-containing monooxygenase / 0.766
2yls FADPhenylacetone monooxygenase 1.14.13.92 0.765
3int FDAUDP-galactopyranose mutase 5.4.99.9 0.765
4mok FADPyranose 2-oxidase / 0.764
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.762
4mih FADPyranose 2-oxidase 1.1.3.10 0.762
2gvc FADThiol-specific monooxygenase 1.14.13 0.761
2ylr FADPhenylacetone monooxygenase 1.14.13.92 0.755
3kkj FADRenalase / 0.755
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.752
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.751
3ish FADThioredoxin reductase 1.8.1.9 0.750
3nlc FADUncharacterized protein / 0.749
2gv8 FADThiol-specific monooxygenase 1.14.13 0.747
3qj4 FADRenalase / 0.747
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.746
2igo FADPyranose 2-oxidase / 0.745
2iid FADL-amino-acid oxidase 1.4.3.2 0.744
3cgb FADCoenzyme A disulfide reductase / 0.744
3pl8 FADPyranose 2-oxidase / 0.744
2yg4 FADPutrescine oxidase / 0.741
2ylt FADPhenylacetone monooxygenase 1.14.13.92 0.740
3lsm SFDPyranose 2-oxidase / 0.740
3ka7 FADPutative oxidoreductase / 0.739
4mo2 FADUDP-galactopyranose mutase / 0.739
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.734
3k4c FADPyranose 2-oxidase / 0.734
1i8t FADUDP-galactopyranose mutase 5.4.99.9 0.733
2r0c FADPutative FAD-monooxygenase / 0.733
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.733
1y56 ATPUncharacterized protein / 0.732
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.732
3lsh FADPyranose 2-oxidase / 0.731
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.731
4fwe FADLysine-specific histone demethylase 1B 1 0.731
1wam FADUDP-galactopyranose mutase 5.4.99.9 0.729
4d03 FADPhenylacetone monooxygenase 1.14.13.92 0.729
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.728
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.725
1nhr FADNADH peroxidase 1.11.1.1 0.724
3ict FADCoenzyme A disulfide reductase / 0.724
1nhq FADNADH peroxidase 1.11.1.1 0.723
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.722
3vqr FADPutative oxidoreductase / 0.722
2bi7 FADUDP-galactopyranose mutase 5.4.99.9 0.721
2eq7 NADDihydrolipoyl dehydrogenase / 0.721
1trb FADThioredoxin reductase 1.8.1.9 0.720
4gdp FADPolyamine oxidase FMS1 / 0.718
4yac NAIC alpha-dehydrogenase / 0.718
2ylw FADPhenylacetone monooxygenase 1.14.13.92 0.717
1k0l FADp-hydroxybenzoate hydroxylase / 0.716
3k30 ADPHistamine dehydrogenase / 0.716
3lsi FADPyranose 2-oxidase / 0.716
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.716
1d4d FADFumarate reductase flavoprotein subunit 1.3.5.4 0.715
2vq7 FADPutative flavin-containing monooxygenase / 0.714
3t2z FADSulfide-quinone reductase / 0.714
4hb9 FADUncharacterized protein / 0.714
4yjd FADD-amino-acid oxidase 1.4.3.3 0.714
1tde FADThioredoxin reductase 1.8.1.9 0.712
2yg3 FADPutrescine oxidase / 0.712
3f8p NADNADH oxidase/thioredoxin reductase / 0.712
1gpe FADGlucose oxidase 1.1.3.4 0.711
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.711
3r9u FADThioredoxin reductase / 0.711
4fwf FADLysine-specific histone demethylase 1B 1 0.711
4gur FADLysine-specific histone demethylase 1B 1 0.711
4jq9 FADDihydrolipoyl dehydrogenase / 0.711
1f8w FADNADH peroxidase 1.11.1.1 0.710
2iw5 FADLysine-specific histone demethylase 1A 1 0.710
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.710
4em4 FADCoenzyme A disulfide reductase / 0.710
1n4v FADCholesterol oxidase 1.1.3.6 0.709
1nhs FADNADH peroxidase 1.11.1.1 0.709
4at0 FADPossible succinate dehydrogenase / 0.709
1ijh FADCholesterol oxidase 1.1.3.6 0.708
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.708
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.708
1pdh FASp-hydroxybenzoate hydroxylase / 0.708
2eq6 FADDihydrolipoyl dehydrogenase / 0.708
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.707
1h81 FADPolyamine oxidase 1.5.3.14 0.707
3f8d FADNADH oxidase/thioredoxin reductase / 0.707
2ign FADPyranose 2-oxidase / 0.706
3b6d FAECholesterol oxidase 1.1.3.6 0.706
3k4n FADPyranose 2-oxidase / 0.706
1cc2 FADCholesterol oxidase 1.1.3.6 0.705
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.705
2ym1 FADPhenylacetone monooxygenase 1.14.13.92 0.705
4u2t FADCholesterol oxidase 1.1.3.6 0.705
3cnt FADPolyamine oxidase FMS1 / 0.703
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.702
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.702
3cge FADCoenzyme A disulfide reductase / 0.702
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.702
2e1m FADL-glutamate oxidase / 0.701
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.701
4gut FADLysine-specific histone demethylase 1B 1 0.701
4tm3 FADKtzI / 0.701
4ech FADPolyamine oxidase FMS1 / 0.700
4usr FADMonooxygenase / 0.699
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.698
4aox FADSteroid monooxygenase / 0.698
2xlr FADPutative flavin-containing monooxygenase / 0.697
4xbf FADLysine-specific histone demethylase 1A 1 0.697
1b8s FADCholesterol oxidase 1.1.3.6 0.696
3t2k FADSulfide-quinone reductase / 0.696
1cf3 FADGlucose oxidase 1.1.3.4 0.695
1tdf FADThioredoxin reductase 1.8.1.9 0.695
2dw4 FADLysine-specific histone demethylase 1A 1 0.695
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.695
2xvf FADPutative flavin-containing monooxygenase / 0.695
1d7l RFLp-hydroxybenzoate hydroxylase / 0.694
2gqw FADFerredoxin reductase / 0.694
3f8r NAPNADH oxidase/thioredoxin reductase / 0.694
3t37 FADPyridoxine 4-oxidase / 0.693
4dsg FADUncharacterized protein / 0.693
2gew FADCholesterol oxidase 1.1.3.6 0.692
2xvi FADPutative flavin-containing monooxygenase / 0.692
1n4u FAECholesterol oxidase 1.1.3.6 0.691
2hqm FADGlutathione reductase 1.8.1.7 0.691
3cnj FADCholesterol oxidase 1.1.3.6 0.691
3we0 FADLysine 2-monooxygenase / 0.691
4tm4 FDAKtzI / 0.691
4xwr FADCholesterol oxidase 1.1.3.6 0.691
1cbo FADCholesterol oxidase 1.1.3.6 0.690
2eq7 FADDihydrolipoyl dehydrogenase / 0.690
2gqf FADUncharacterized protein HI_0933 / 0.690
2rgh FADAlpha-Glycerophosphate Oxidase / 0.690
3qvr FADGlucose oxidase 1.1.3.4 0.690
4u2s FDACholesterol oxidase 1.1.3.6 0.690
5cku FADL-ornithine N(5)-monooxygenase / 0.690
3gyi FADCholesterol oxidase 1.1.3.6 0.689
1ges FADGlutathione reductase 1.8.1.7 0.688
2xvh FADPutative flavin-containing monooxygenase / 0.688
4mo2 FDAUDP-galactopyranose mutase / 0.688
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.687
2jae FADL-amino acid oxidase / 0.687
2npx FADNADH peroxidase 1.11.1.1 0.687
3kyb FADUDP-galactopyranose mutase 5.4.99.9 0.687
3t14 FADSulfide-quinone reductase / 0.687
4u2l SFDCholesterol oxidase 1.1.3.6 0.687
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.686
4hsu FADLysine-specific histone demethylase 1B 1 0.686
4u8m FDAUDP-galactopyranose mutase / 0.686
1yy5 FADPolyamine oxidase FMS1 / 0.685
2xls FADPutative flavin-containing monooxygenase / 0.685
3icr FADCoenzyme A disulfide reductase / 0.685
4j2w FADKynurenine 3-monooxygenase / 0.685
2q0l FADThioredoxin reductase 1.8.1.9 0.684
3hdy FADUDP-galactopyranose mutase / 0.684
4eqw FADCoenzyme A disulfide reductase / 0.684
3gyj FADCholesterol oxidase 1.1.3.6 0.683
4b63 FADL-ornithine N(5)-monooxygenase / 0.683
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.681
2bry FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.681
2rgj FADFlavin-containing monooxygenase / 0.681
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.680
3alj FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.680
3bg7 FADPyranose 2-oxidase / 0.680
4b65 FADL-ornithine N(5)-monooxygenase / 0.680
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.679
1b4v FADCholesterol oxidase 1.1.3.6 0.678
3t2y FADSulfide-quinone reductase / 0.678
1knp FADL-aspartate oxidase 1.4.3.16 0.677
4tm1 FDAKtzI / 0.677
3nn6 FB06-hydroxy-L-nicotine oxidase / 0.676
1zx9 FADMercuric reductase 1.16.1.1 0.675
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.674
4b66 FADL-ornithine N(5)-monooxygenase / 0.674
2cdu ADPNADH oxidase / 0.673
2ji6 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.673
1p1h NADInositol-3-phosphate synthase 5.5.1.4 0.672
4emw FADCoenzyme A disulfide reductase / 0.672
4gus FADLysine-specific histone demethylase 1B 1 0.672
4rek FADCholesterol oxidase 1.1.3.6 0.672
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.672
1feb FADTrypanothione reductase 1.8.1.12 0.671
1joa FADNADH peroxidase 1.11.1.1 0.671
1mxt FAECholesterol oxidase 1.1.3.6 0.671
1nhp FADNADH peroxidase 1.11.1.1 0.671
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.670
1djq ADPTrimethylamine dehydrogenase 1.5.8.2 0.669
3k7t FAD6-hydroxy-L-nicotine oxidase / 0.669
4k5r FADOxygenase / 0.669
2zbw FADFerredoxin--NADP reductase / 0.668
3kpf FADPolyamine oxidase 1.5.3.14 0.668
3v76 FDAUncharacterized protein / 0.668
1o94 ADPTrimethylamine dehydrogenase 1.5.8.2 0.667
1zmc NADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.667
2vvl FADMonoamine oxidase N 1.4.3.4 0.667
1ng3 FADGlycine oxidase 1.4.3.19 0.666
2x3n FADProbable FAD-dependent monooxygenase / 0.666
3gd3 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.666
1qo8 FADFumarate reductase flavoprotein subunit / 0.665
4a99 FADTetX family tetracycline inactivation enzyme / 0.665
4j36 FADKynurenine 3-monooxygenase / 0.665
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.665
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.665
3g8a SAHRibosomal RNA small subunit methyltransferase G / 0.664
3mj4 FADUDP-galactopyranose mutase / 0.664
1ger FADGlutathione reductase 1.8.1.7 0.663
2yg7 FADPutrescine oxidase / 0.663
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.663
4tlx FDAKtzI / 0.663
4txi FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.663
2yg5 FADPutrescine oxidase / 0.662
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.662
4plp NADHomospermidine synthase 2.5.1.44 0.662
1e1n FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.661
1i9g SAMtRNA (adenine(58)-N(1))-methyltransferase TrmI / 0.661
1z6l FADPolyamine oxidase FMS1 / 0.661
4bk2 FADProbable salicylate monooxygenase / 0.661
4ysh FADGlycine oxidase / 0.661
1gal FADGlucose oxidase 1.1.3.4 0.660
2b9w FADPutative aminooxidase / 0.660
2xlp FADPutative flavin-containing monooxygenase / 0.660
3sz0 FADSulfide-quinone reductase / 0.660
4nte FADDepH / 0.660
5c2t FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.660
3axb FADPutative oxidoreductase / 0.659
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.659
1f8r FADL-amino-acid oxidase 1.4.3.2 0.658
2bab FADPutative aminooxidase / 0.658
3he3 FADUDP-galactopyranose mutase / 0.658
2v3a FADRubredoxin-NAD(+) reductase 1.18.1.1 0.657
3cox FADCholesterol oxidase 1.1.3.6 0.657
3l8k ADPDihydrolipoamide dehydrogenase (PdhD-3) / 0.657
2ba9 FADPutative aminooxidase / 0.656
3ics FADCoenzyme A disulfide reductase / 0.656
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.655
2bra FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.655
3cgd FADCoenzyme A disulfide reductase / 0.655
3cty FADProbable thioredoxin reductase / 0.655
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.655
1cl0 FADThioredoxin reductase 1.8.1.9 0.654
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.654
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.654
2r9z FADGlutathione amide reductase / 0.654
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.654
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.653
3qvs NADMyo-inositol-1-phosphate synthase (Ino1) / 0.653
2ptf FMNUncharacterized protein MTH_863 / 0.652
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.652
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.651
3fpz AHZThiamine thiazole synthase / 0.651
4bk3 FADProbable salicylate monooxygenase / 0.651
5fa5 MTAProtein arginine N-methyltransferase 5 / 0.651
1h2h NADL-aspartate dehydrogenase 1.4.1.21 0.650
1v59 NADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.650
2vqb FADPutative flavin-containing monooxygenase / 0.650
3qvp FADGlucose oxidase 1.1.3.4 0.650