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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3uo5 0BX Aurora kinase A 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3uo5 0BXAurora kinase A 2.7.11.1 1.071
4dea NHIAurora kinase A 2.7.11.1 0.961
2np8 CC3Aurora kinase A 2.7.11.1 0.784
4ji9 1M3Tyrosine-protein kinase JAK2 / 0.757
3efw AK8Aurora kinase A 2.7.11.1 0.724
5dr9 SKEAurora kinase A 2.7.11.1 0.713
1oec AA2Fibroblast growth factor receptor 2 / 0.712
3cjf SAVVascular endothelial growth factor receptor 2 2.7.10.1 0.708
2x81 ZZLAurora kinase A 2.7.11.1 0.703
4iwq 1FVSerine/threonine-protein kinase TBK1 2.7.11.1 0.703
5dpv SKEAurora kinase A 2.7.11.1 0.702
5dt0 SKEAurora kinase A 2.7.11.1 0.702
4im2 BX7Serine/threonine-protein kinase TBK1 2.7.11.1 0.701
2x4f 16XMyosin light chain kinase family member 4 2.7.11.1 0.697
5dr6 SKEAurora kinase A 2.7.11.1 0.697
2bdf 24AProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.693
4b6l 9ZPSerine/threonine-protein kinase PLK3 2.7.11.21 0.693
4j53 1J4Serine/threonine-protein kinase PLK1 2.7.11.21 0.693
4iwo 1H4Serine/threonine-protein kinase TBK1 2.7.11.1 0.684
3cjg KIMVascular endothelial growth factor receptor 2 2.7.10.1 0.681
4eut BX7Serine/threonine-protein kinase TBK1 2.7.11.1 0.677
4fko 20KCyclin-dependent kinase 2 2.7.11.22 0.674
2j9m PY8Cyclin-dependent kinase 2 2.7.11.22 0.671
4aot GW8Serine/threonine-protein kinase 10 2.7.11.1 0.671
2xb7 GUIALK tyrosine kinase receptor 2.7.10.1 0.670
1pxm CK5Cyclin-dependent kinase 2 2.7.11.22 0.666
4bgh 3I6Cyclin-dependent kinase 2 2.7.11.22 0.666
3sw4 18KCyclin-dependent kinase 2 2.7.11.22 0.664
2xck MH43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.663
2hzi JINTyrosine-protein kinase ABL1 2.7.10.2 0.662
2rku R78Serine/threonine-protein kinase PLK1 2.7.11.21 0.660
2c5y MTWCyclin-dependent kinase 2 2.7.11.22 0.659
2vv9 IM9Cyclin-dependent kinase 2 2.7.11.22 0.658
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.657
3elj GS7Mitogen-activated protein kinase 8 2.7.11.24 0.655
2c5n CK8Cyclin-dependent kinase 2 2.7.11.22 0.653
3i5z Z48Mitogen-activated protein kinase 1 2.7.11.24 0.652
4b0g VEKAurora kinase A 2.7.11.1 0.652
4i5c C5ITyrosine-protein kinase JAK1 / 0.652
2jko BIJFocal adhesion kinase 1 2.7.10.2 0.651