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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3um5 CP6 Bifunctional dihydrofolate reductase-thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3um5 CP6Bifunctional dihydrofolate reductase-thymidylate synthase / 0.947
3qfx CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.802
2bl9 CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.780
3qgt CP6Bifunctional dihydrofolate reductase-thymidylate synthase / 0.761
4ddr MMVDihydrofolate reductase 1.5.1.3 0.739
2blc CP7Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.732
3qg2 CP6Bifunctional dihydrofolate reductase-thymidylate synthase / 0.727
2blb CP7Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.719
3qls 55VDihydrofolate reductase 1.5.1.3 0.707
1j3j CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.706
2bla CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.704
1dg7 WRBDihydrofolate reductase 1.5.1.3 0.701
1ia2 TQ4Dihydrofolate reductase 1.5.1.3 0.698
3um8 1CYBifunctional dihydrofolate reductase-thymidylate synthase / 0.690
4h97 53SDihydrofolate reductase 1.5.1.3 0.677
3sgy 06WDihydrofolate reductase 1.5.1.3 0.667
3k45 51PDihydrofolate reductase 1.5.1.3 0.666
1hfq MOTDihydrofolate reductase 1.5.1.3 0.660
3sa2 7DRDihydrofolate reductase / 0.652
3irm 1CYBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.650