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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3ugc 046 Tyrosine-protein kinase JAK2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3ugc 046Tyrosine-protein kinase JAK2 / 1.290
4u0i 0LIMast/stem cell growth factor receptor Kit 2.7.10.1 0.845
3wze BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.835
4asd BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.816
3vhe 42QVascular endothelial growth factor receptor 2 2.7.10.1 0.803
3gcs BAXMitogen-activated protein kinase 14 / 0.777
3rgf BAXCyclin-dependent kinase 8 2.7.11.22 0.773
4tyj 0LIFibroblast growth factor receptor 4 2.7.10.1 0.762
5hi2 BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.761
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.746
2hzn KINTyrosine-protein kinase ABL1 2.7.10.2 0.736
1ywn LIFVascular endothelial growth factor receptor 2 2.7.10.1 0.721
4c8b 0LIReceptor-interacting serine/threonine-protein kinase 2 2.7.11.1 0.720
2hz0 GINTyrosine-protein kinase ABL1 2.7.10.2 0.714
1uwh BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.704
3el8 PD5Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.701
2osc MUHAngiopoietin-1 receptor 2.7.10.1 0.699
4ckr DI1Epithelial discoidin domain-containing receptor 1 2.7.10.1 0.697
4agw NG7Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.695
3p7c P7CMitogen-activated protein kinase 14 / 0.688
3gi3 B10Mitogen-activated protein kinase 14 / 0.687
3b2w 9NHTyrosine-protein kinase Lck 2.7.10.2 0.673
4eyj N61Mitogen-activated protein kinase 13 2.7.11.24 0.673
3p5k P5KMitogen-activated protein kinase 14 / 0.672
3o8u BMUMitogen-activated protein kinase 14 / 0.671
4at4 T6EBDNF/NT-3 growth factors receptor 2.7.10.1 0.671
4v01 0LIFibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b / 0.671
3dko IHZEphrin type-A receptor 7 2.7.10.1 0.664
3p7b P7BMitogen-activated protein kinase 14 / 0.659
4neu Q1AReceptor-interacting serine/threonine-protein kinase 1 2.7.11.1 0.659
3ce3 1FNHepatocyte growth factor receptor 2.7.10.1 0.652
3cs9 NILTyrosine-protein kinase ABL1 2.7.10.2 0.650