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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3tub FPU Tyrosine-protein kinase SYK 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3tub FPUTyrosine-protein kinase SYK 2.7.10.2 1.297
4fny I3KALK tyrosine kinase receptor 2.7.10.1 0.771
4ase AV9Vascular endothelial growth factor receptor 2 2.7.10.1 0.738
4eyj N61Mitogen-activated protein kinase 13 2.7.11.24 0.738
2rl5 2RLVascular endothelial growth factor receptor 2 2.7.10.1 0.729
1ywn LIFVascular endothelial growth factor receptor 2 2.7.10.1 0.693
4otw DB8Receptor tyrosine-protein kinase erbB-3 2.7.10.1 0.690
3hv3 R49Mitogen-activated protein kinase 14 / 0.684
3rgf BAXCyclin-dependent kinase 8 2.7.11.22 0.683
4neu Q1AReceptor-interacting serine/threonine-protein kinase 1 2.7.11.1 0.678
5hi2 BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.678
2hzn KINTyrosine-protein kinase ABL1 2.7.10.2 0.665
3gcs BAXMitogen-activated protein kinase 14 / 0.659
4eym 0RXMitogen-activated protein kinase 13 2.7.11.24 0.658
4uxq 0LIFibroblast growth factor receptor 4 2.7.10.1 0.655
3hv4 L51Mitogen-activated protein kinase 14 / 0.652
5amn DTQProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.652
4deg 0JJHepatocyte growth factor receptor 2.7.10.1 0.651