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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3tpr 5HA Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3tpr 5HABeta-secretase 1 3.4.23.46 1.128
2b8l 5HABeta-secretase 1 3.4.23.46 0.931
4fco 0U4Beta-secretase 1 3.4.23.46 0.905
2b8v 3BNBeta-secretase 1 3.4.23.46 0.888
2vie VG0Beta-secretase 1 3.4.23.46 0.826
2p8h MY9Beta-secretase 1 3.4.23.46 0.810
3ixj 586Beta-secretase 1 3.4.23.46 0.796
2xfi XFIBeta-secretase 1 3.4.23.46 0.793
2vkm BSDBeta-secretase 1 3.4.23.46 0.791
2viz VG4Beta-secretase 1 3.4.23.46 0.789
3i25 MV7Beta-secretase 1 3.4.23.46 0.781
4dpf 0LGBeta-secretase 1 3.4.23.46 0.780
2xfk AA9Beta-secretase 1 3.4.23.46 0.775
2vj6 VG5Beta-secretase 1 3.4.23.46 0.773
2wf4 ZY4Beta-secretase 1 3.4.23.46 0.762
3ixk 929Beta-secretase 1 3.4.23.46 0.761
3dm6 757Beta-secretase 1 3.4.23.46 0.751
3cib 314Beta-secretase 1 3.4.23.46 0.745
3lpk Z76Beta-secretase 1 3.4.23.46 0.743
2wez ZYEBeta-secretase 1 3.4.23.46 0.742
2p4j 23IBeta-secretase 1 3.4.23.46 0.741
4k9h 1QUBeta-secretase 1 3.4.23.46 0.741
3ohh 3HHBeta-secretase 1 3.4.23.46 0.734
3lpj Z75Beta-secretase 1 3.4.23.46 0.732
3cic 316Beta-secretase 1 3.4.23.46 0.730
2qzl IXSBeta-secretase 1 3.4.23.46 0.728
3ohf 3HFBeta-secretase 1 3.4.23.46 0.728
1w51 L01Beta-secretase 1 3.4.23.46 0.725
2wf0 ZY0Beta-secretase 1 3.4.23.46 0.725
4dus 0MPBeta-secretase 1 3.4.23.46 0.724
2vnm CM8Beta-secretase 1 3.4.23.46 0.722
3qbh QBHBeta-secretase 1 3.4.23.46 0.722
2vj7 VG6Beta-secretase 1 3.4.23.46 0.720
4k8s 1QTBeta-secretase 1 3.4.23.46 0.719
4dpi 0N1Beta-secretase 1 3.4.23.46 0.717
3lpi Z74Beta-secretase 1 3.4.23.46 0.715
3k5g BJCBeta-secretase 1 3.4.23.46 0.711
4ewo 996Beta-secretase 1 3.4.23.46 0.706
4dh6 0KNBeta-secretase 1 3.4.23.46 0.704
4exg 916Beta-secretase 1 3.4.23.46 0.694
4ke1 1R6Beta-secretase 1 3.4.23.46 0.688
2oah QINBeta-secretase 1 3.4.23.46 0.682
2iqg F2IBeta-secretase 1 3.4.23.46 0.678
1tqf 32PBeta-secretase 1 3.4.23.46 0.670
2irz I02Beta-secretase 1 3.4.23.46 0.667
2p83 MR0Beta-secretase 1 3.4.23.46 0.667
3pi5 3P5Beta-secretase 1 3.4.23.46 0.666
3r2f PB0Beta-secretase 1 3.4.23.46 0.666
2hiz LIJBeta-secretase 1 3.4.23.46 0.665
4gid 0GHBeta-secretase 1 3.4.23.46 0.658
3k5c 0BIBeta-secretase 1 3.4.23.46 0.655