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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3ti1 B49 Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3ti1 B49Cyclin-dependent kinase 2 2.7.11.22 1.193
4fkp LS5Cyclin-dependent kinase 2 2.7.11.22 0.804
1ke5 LS1Cyclin-dependent kinase 2 2.7.11.22 0.783
4fkt 48KCyclin-dependent kinase 2 2.7.11.22 0.773
1fvt 106Cyclin-dependent kinase 2 2.7.11.22 0.772
4fkv 61KCyclin-dependent kinase 2 2.7.11.22 0.768
1p2a 5BNCyclin-dependent kinase 2 2.7.11.22 0.760
1ke9 LS5Cyclin-dependent kinase 2 2.7.11.22 0.745
3py0 SU9Cyclin-dependent kinase 2 2.7.11.22 0.740
1ke8 LS4Cyclin-dependent kinase 2 2.7.11.22 0.738
3hzt J60Calmodulin-like domain protein kinase isoform 3 / 0.727
1v0o INRCell division control protein 2 homolog 2.7.11.22 0.722
2gdo 12CSerine/threonine-protein kinase Chk1 2.7.11.1 0.712
4fkr 45KCyclin-dependent kinase 2 2.7.11.22 0.712
4fks 46KCyclin-dependent kinase 2 2.7.11.22 0.705
2jam J60Calcium/calmodulin-dependent protein kinase type 1G 2.7.11.17 0.704
3r8p Z46Cyclin-dependent kinase 2 2.7.11.22 0.704
4qmz B49Serine/threonine-protein kinase 24 2.7.11.1 0.695
2uzt SS3cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.689
4ks8 B49Serine/threonine-protein kinase PAK 6 2.7.11.1 0.688
2uzu L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.687
3kkv B99cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.687
2x2m X2MProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.680
1e9h INRCyclin-dependent kinase 2 2.7.11.22 0.679
1ke7 LS3Cyclin-dependent kinase 2 2.7.11.22 0.679
2bhe BRYCyclin-dependent kinase 2 2.7.11.22 0.679
2vtj LZ4Cyclin-dependent kinase 2 2.7.11.22 0.679
2vti LZ3Cyclin-dependent kinase 2 2.7.11.22 0.677
2hxq 373Serine/threonine-protein kinase Chk1 2.7.11.1 0.676
2x2l X2LProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.675
3lfq A28Cyclin-dependent kinase 2 2.7.11.22 0.674
2f2u M77Rho-associated protein kinase 2 2.7.11.1 0.673
3bgq VX2Serine/threonine-protein kinase pim-1 2.7.11.1 0.670
3tki S25Serine/threonine-protein kinase Chk1 2.7.11.1 0.670
2jds L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.668
4fsu HK5Serine/threonine-protein kinase Chk1 2.7.11.1 0.667
1qpj STUTyrosine-protein kinase Lck 2.7.10.2 0.666
2b52 D42Cyclin-dependent kinase 2 2.7.11.22 0.666
3l9m L9McAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.666
1m2r MNYCasein kinase II subunit alpha 2.7.11.1 0.661
2uzv SS5cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
2yi5 YI5Heat shock protein HSP 90-alpha / 0.661
3lfn A27Cyclin-dependent kinase 2 2.7.11.22 0.661
2gnh H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
4ag8 AXIVascular endothelial growth factor receptor 2 2.7.10.1 0.660
1fvv 107Cyclin-dependent kinase 2 2.7.11.22 0.658
3eb0 DRKUncharacterized protein / 0.656
3l1s Z92Glycogen synthase kinase-3 beta 2.7.11.26 0.656
3q9z TXQCasein kinase II subunit alpha 2.7.11.1 0.656
1fuy FIPTryptophan synthase alpha chain / 0.654
2x2k X2KProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.654
4fsq HK3Serine/threonine-protein kinase Chk1 2.7.11.1 0.652
4ftl H0KSerine/threonine-protein kinase Chk1 2.7.11.1 0.652
2gni M77cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650
2uzw SS4cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650
4fsm HK1Serine/threonine-protein kinase Chk1 2.7.11.1 0.650