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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3td8 D2R Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3td8 D2RDihydrofolate reductase 1.5.1.3 1.304
2fzi DH3Dihydrofolate reductase 1.5.1.3 0.812
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.788
1u70 MTXDihydrofolate reductase 1.5.1.3 0.755
4ixg IXGDihydrofolate reductase 1.5.1.3 0.748
1hfr MOTDihydrofolate reductase 1.5.1.3 0.746
3tq9 MTXDihydrofolate reductase / 0.740
1dls MTXDihydrofolate reductase 1.5.1.3 0.730
1u71 MXADihydrofolate reductase 1.5.1.3 0.721
2d0k FOLDihydrofolate reductase 1.5.1.3 0.713
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.712
1hfp MOTDihydrofolate reductase 1.5.1.3 0.704
1dyh DZFDihydrofolate reductase 1.5.1.3 0.703
1ohk COPDihydrofolate reductase 1.5.1.3 0.702
2dhf DZFDihydrofolate reductase 1.5.1.3 0.699
4p68 MTXDihydrofolate reductase / 0.698
3ia4 MTXDihydrofolate reductase / 0.692
1odn APVIsopenicillin N synthase 1.21.3.1 0.686
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.685
3drc MTXDihydrofolate reductase 1.5.1.3 0.681
4x5i FOLDihydrofolate reductase 1.5.1.3 0.680
5hi6 MTXDihydrofolate reductase / 0.679
1df7 MTXDihydrofolate reductase 1.5.1.3 0.678
1hfq MOTDihydrofolate reductase 1.5.1.3 0.673
1mvt DTMDihydrofolate reductase 1.5.1.3 0.673
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.673
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.670
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.669
4dfr MTXDihydrofolate reductase 1.5.1.3 0.669
1mvs DTMDihydrofolate reductase 1.5.1.3 0.668
3k45 51PDihydrofolate reductase 1.5.1.3 0.668
4kow CFXUncharacterized protein / 0.665
1ly3 COGDihydrofolate reductase 1.5.1.3 0.664
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.664
1dyj DDFDihydrofolate reductase 1.5.1.3 0.662
1u4s BIHL-lactate dehydrogenase 1.1.1.27 0.661
4ixe IXEDihydrofolate reductase 1.5.1.3 0.661
2g1m 4HGEgl nine homolog 1 / 0.660
4x5h FOLDihydrofolate reductase 1.5.1.3 0.659
3och 2MXDihydrofolate reductase 1.5.1.3 0.658
1qjf ACSIsopenicillin N synthase 1.21.3.1 0.657
1dra MTXDihydrofolate reductase 1.5.1.3 0.655
1gir NDPIota toxin component Ia / 0.654
4kfj FOLDihydrofolate reductase 1.5.1.3 0.654
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.653
1kms LIHDihydrofolate reductase 1.5.1.3 0.652
1m78 CLZDihydrofolate reductase 1.5.1.3 0.652
4kox CLSUncharacterized protein / 0.652
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.650