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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3sz0 FAD Sulfide-quinone reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3sz0 FADSulfide-quinone reductase / 1.163
3t14 FADSulfide-quinone reductase / 1.075
3t2k FADSulfide-quinone reductase / 1.065
3syi FADSulfide-quinone reductase / 1.060
3kpk FADSulfide-quinone reductase / 1.058
3t2z FADSulfide-quinone reductase / 1.002
3t2y FADSulfide-quinone reductase / 0.989
3cgc FADCoenzyme A disulfide reductase / 0.792
3cgd FADCoenzyme A disulfide reductase / 0.791
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.789
4hb9 FADUncharacterized protein / 0.778
3cge FADCoenzyme A disulfide reductase / 0.772
2tpr FADTrypanothione reductase 1.8.1.12 0.759
2hqm FADGlutathione reductase 1.8.1.7 0.756
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.755
2gv8 FADThiol-specific monooxygenase 1.14.13 0.747
3cgb FADCoenzyme A disulfide reductase / 0.746
1d4d FADFumarate reductase flavoprotein subunit 1.3.5.4 0.745
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.745
2v6o FADThioredoxin glutathione reductase / 0.744
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.739
4fk1 FADPutative thioredoxin reductase / 0.739
4b64 FADL-ornithine N(5)-monooxygenase / 0.734
1pdh FASp-hydroxybenzoate hydroxylase / 0.733
3icr FADCoenzyme A disulfide reductase / 0.732
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.731
2eq6 FADDihydrolipoyl dehydrogenase / 0.731
3ics FADCoenzyme A disulfide reductase / 0.730
3g5q FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.728
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.727
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.725
4nzh FADL-ornithine N(5)-monooxygenase / 0.724
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.724
2eq8 FADDihydrolipoyl dehydrogenase / 0.723
2gr0 FADFerredoxin reductase / 0.723
3ish FADThioredoxin reductase 1.8.1.9 0.722
1w4x FADPhenylacetone monooxygenase 1.14.13.92 0.721
5c2t FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.721
4ntd FADThioredoxin reductase / 0.719
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.718
1f3p FADFerredoxin reductase / 0.718
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.717
1ng3 FADGlycine oxidase 1.4.3.19 0.717
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.716
4dsg FADUncharacterized protein / 0.715
2gvc FADThiol-specific monooxygenase 1.14.13 0.714
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.714
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.713
2e1m FADL-glutamate oxidase / 0.713
3bi2 FADPolyamine oxidase FMS1 / 0.711
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.710
4b69 FADL-ornithine N(5)-monooxygenase / 0.710
4dsh FDAUncharacterized protein / 0.706
4j57 FADThioredoxin reductase 2 1.8.1.9 0.704
1get FADGlutathione reductase 1.8.1.7 0.703
1e1n FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.702
3r9u FADThioredoxin reductase / 0.702
1cbo FADCholesterol oxidase 1.1.3.6 0.701
1ijh FADCholesterol oxidase 1.1.3.6 0.701
1mxt FAECholesterol oxidase 1.1.3.6 0.700
1n1p FADCholesterol oxidase 1.1.3.6 0.700
1n4v FADCholesterol oxidase 1.1.3.6 0.700
1n4w FADCholesterol oxidase 1.1.3.6 0.700
3s5w FADL-ornithine N(5)-monooxygenase / 0.700
4a99 FADTetX family tetracycline inactivation enzyme / 0.700
4u2t FADCholesterol oxidase 1.1.3.6 0.700
4xxg FADCholesterol oxidase 1.1.3.6 0.700
5hhf FDAUDP-galactopyranose mutase / 0.700
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.698
3ict FADCoenzyme A disulfide reductase / 0.697
3utg FDAUDP-galactopyranose mutase / 0.697
4u8k FDAUDP-galactopyranose mutase / 0.697
3t37 FADPyridoxine 4-oxidase / 0.696
4nte FADDepH / 0.696
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.695
3rha FDAPutrescine oxidase / 0.694
3up5 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.693
4x4j FADPutative oxygenase / 0.693
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.692
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.692
4u8l FDAUDP-galactopyranose mutase / 0.689
4wx1 FDAUDP-galactopyranose mutase / 0.689
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.687
2ylr FADPhenylacetone monooxygenase 1.14.13.92 0.687
3f8p NADNADH oxidase/thioredoxin reductase / 0.687
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.685
3f8r NAPNADH oxidase/thioredoxin reductase / 0.685
4b63 FADL-ornithine N(5)-monooxygenase / 0.685
4gdc FADUDP-galactopyranose mutase / 0.685
1djq ADPTrimethylamine dehydrogenase 1.5.8.2 0.684
3awi FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC 1.5 0.684
4gcm FADThioredoxin reductase 1.8.1.9 0.684
4tm3 FADKtzI / 0.684
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.683
1geu FADGlutathione reductase 1.8.1.7 0.682
1h83 FADPolyamine oxidase 1.5.3.14 0.682
2x8h FADThioredoxin glutathione reductase / 0.682
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.682
4emw FADCoenzyme A disulfide reductase / 0.682
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.681
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.681
4nev FADTrypanothione reductase / 0.681
1feb FADTrypanothione reductase 1.8.1.12 0.680
2q0k FADThioredoxin reductase 1.8.1.9 0.680
2xve FADPutative flavin-containing monooxygenase / 0.680
3ukk FDAUDP-galactopyranose mutase / 0.680
3we0 FADLysine 2-monooxygenase / 0.680
4tm1 FDAKtzI / 0.680
4ysh FADGlycine oxidase / 0.680
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.679
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.678
2q0l FADThioredoxin reductase 1.8.1.9 0.678
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.678
4cnj FADL-amino acid oxidase / 0.678
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.677
1o94 ADPTrimethylamine dehydrogenase 1.5.8.2 0.677
3lov FADProtoporphyrinogen oxidase / 0.677
4eqs FADCoenzyme A disulfide reductase / 0.677
4usr FADMonooxygenase / 0.677
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.676
2yg5 FADPutrescine oxidase / 0.676
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.676
1ger FADGlutathione reductase 1.8.1.7 0.675
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.675
3uka FADUDP-galactopyranose mutase / 0.675
4eqx FADCoenzyme A disulfide reductase / 0.675
2eq7 FADDihydrolipoyl dehydrogenase / 0.674
4b66 FADL-ornithine N(5)-monooxygenase / 0.674
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.673
2gr3 FADFerredoxin reductase / 0.673
3gwf FADCyclohexanone monooxygenase / 0.673
4em3 FADCoenzyme A disulfide reductase / 0.673
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.672
3gyj FADCholesterol oxidase 1.1.3.6 0.672
4tm4 FDAKtzI / 0.672
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.672
4tlx FDAKtzI / 0.671
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.670
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.670
4h4y FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.670
1nhr FADNADH peroxidase 1.11.1.1 0.669
1typ FADTrypanothione reductase 1.8.1.12 0.669
2eq9 FADDihydrolipoyl dehydrogenase / 0.669
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.669
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.668
1nhp FADNADH peroxidase 1.11.1.1 0.668
2cul FADGidA-related protein / 0.668
3ukf FDAUDP-galactopyranose mutase / 0.668
4g9k FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.668
4mo2 FDAUDP-galactopyranose mutase / 0.667
1i8t FADUDP-galactopyranose mutase 5.4.99.9 0.666
1nhq FADNADH peroxidase 1.11.1.1 0.666
1yqz FADCoenzyme A disulfide reductase / 0.666
3ukk FADUDP-galactopyranose mutase / 0.666
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.665
3lad FADDihydrolipoyl dehydrogenase / 0.665
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.665
4h4z FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.665
4rek FADCholesterol oxidase 1.1.3.6 0.665
2eq7 NADDihydrolipoyl dehydrogenase / 0.664
3gd3 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.664
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.664
4b65 FADL-ornithine N(5)-monooxygenase / 0.664
3cox FADCholesterol oxidase 1.1.3.6 0.663
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.662
1joa FADNADH peroxidase 1.11.1.1 0.662
1q1r FADPutidaredoxin reductase 1.18.1.5 0.662
2v3a FADRubredoxin-NAD(+) reductase 1.18.1.1 0.662
2ylt FADPhenylacetone monooxygenase 1.14.13.92 0.662
2ym1 FADPhenylacetone monooxygenase 1.14.13.92 0.662
3c96 FADFlavin-containing monooxygenase / 0.661
4b68 FADL-ornithine N(5)-monooxygenase / 0.661
4bur FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.661
5cku FADL-ornithine N(5)-monooxygenase / 0.661
1bzl FADTrypanothione reductase 1.8.1.12 0.660
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.660
1tdf FADThioredoxin reductase 1.8.1.9 0.660
3l8k ADPDihydrolipoamide dehydrogenase (PdhD-3) / 0.660
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.660
1q1w FADPutidaredoxin reductase 1.18.1.5 0.659
3ada NADSubunit alpha of sarocosine oxidase / 0.659
2ylz FADPhenylacetone monooxygenase 1.14.13.92 0.658
3g5s FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.658
4yac NAIC alpha-dehydrogenase / 0.658
1y56 ATPUncharacterized protein / 0.657
2npx FADNADH peroxidase 1.11.1.1 0.657
2iid FADL-amino-acid oxidase 1.4.3.2 0.656
3fg2 FADPutative rubredoxin reductase / 0.656
4g6g FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.656
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.655
2r0c FADPutative FAD-monooxygenase / 0.655
4g73 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.655
1reo FADL-amino-acid oxidase 1.4.3.2 0.654
2xvi FADPutative flavin-containing monooxygenase / 0.654
2r9z FADGlutathione amide reductase / 0.653
2ym2 FADPhenylacetone monooxygenase 1.14.13.92 0.653
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.653
3int FDAUDP-galactopyranose mutase 5.4.99.9 0.653
3lb8 FADPutidaredoxin reductase 1.18.1.5 0.653
1nhs FADNADH peroxidase 1.11.1.1 0.652
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.652
2jk6 FADTrypanothione reductase / 0.652
2zbw FADFerredoxin--NADP reductase / 0.652
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.652
3uth FDAUDP-galactopyranose mutase / 0.652
4ccr FADThioredoxin reductase / 0.652
2qa1 FADPgaE / 0.651
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.651
3fpz AHZThiamine thiazole synthase / 0.651
3jsk AHZThiamine thiazole synthase / 0.651
4ap3 FADSteroid monooxygenase / 0.651
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.650
1tdn FADL-amino-acid oxidase 1.4.3.2 0.650
3cnj FADCholesterol oxidase 1.1.3.6 0.650