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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3srs M23 Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3srs M23Dihydrofolate reductase 1.5.1.3 1.056
3srr Q20Dihydrofolate reductase 1.5.1.3 0.963
3sr5 Q12Dihydrofolate reductase 1.5.1.3 0.739
2w9g TOPDihydrofolate reductase 1.5.1.3 0.719
3m08 RARDihydrofolate reductase 1.5.1.3 0.711
3srw Q27Dihydrofolate reductase 1.5.1.3 0.701
3sru Q26Dihydrofolate reductase 1.5.1.3 0.684
3jwm 5WBDihydrofolate reductase / 0.661
3sqy Q11Dihydrofolate reductase 1.5.1.3 0.654
4elb 34SDihydrofolate reductase / 0.650