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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3sr5 Q12 Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3sr5 Q12Dihydrofolate reductase 1.5.1.3 1.007
3srq Q19Dihydrofolate reductase 1.5.1.3 0.911
3srs M23Dihydrofolate reductase 1.5.1.3 0.739
3sru Q26Dihydrofolate reductase 1.5.1.3 0.701
3m08 RARDihydrofolate reductase 1.5.1.3 0.661
1m79 MQ1Dihydrofolate reductase 1.5.1.3 0.658
2blb CP7Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.653
1ia3 TQ5Dihydrofolate reductase 1.5.1.3 0.650
3hzt J60Calmodulin-like domain protein kinase isoform 3 / 0.650