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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3sa2 7DR Dihydrofolate reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3sa2 7DRDihydrofolate reductase / 1.061
3sai 9DRDihydrofolate reductase / 0.917
3sh2 5DRDihydrofolate reductase 1.5.1.3 0.706
3sa1 6DRDihydrofolate reductase / 0.698
4kak 06UDihydrofolate reductase 1.5.1.3 0.690
4h97 53SDihydrofolate reductase 1.5.1.3 0.689
3i8a N22Dihydrofolate reductase 1.5.1.3 0.685
3sgy 06WDihydrofolate reductase 1.5.1.3 0.672
3qg2 CP6Bifunctional dihydrofolate reductase-thymidylate synthase / 0.669
3qlr QLRDihydrofolate reductase 1.5.1.3 0.662
1hfr MOTDihydrofolate reductase 1.5.1.3 0.660
1j3j CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.659
4xe6 06UDihydrofolate reductase 1.5.1.3 0.656
3um5 CP6Bifunctional dihydrofolate reductase-thymidylate synthase / 0.652
2bl9 CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.651