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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3s8p SAM Histone-lysine N-methyltransferase KMT5B 2.1.1.43

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3s8p SAMHistone-lysine N-methyltransferase KMT5B 2.1.1.43 1.177
4bup SAMHistone-lysine N-methyltransferase KMT5B 2.1.1.43 1.060
4au7 SAHHistone-lysine N-methyltransferase KMT5C 2.1.1.43 0.912
5jhn SAMHistone-lysine N-methyltransferase EHMT2 / 0.718
3ooi SAMHistone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific 2.1.1.43 0.713
3qwp SAMHistone-lysine N-methyltransferase SMYD3 2.1.1.43 0.706
5jj0 SAMHistone-lysine N-methyltransferase EHMT2 / 0.706
4j83 SAMHistone-lysine N-methyltransferase SETD7 2.1.1.43 0.701
2h21 SAMRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic 2.1.1.127 0.698
2r3a SAMHistone-lysine N-methyltransferase SUV39H2 2.1.1.43 0.697
3pdn SFGHistone-lysine N-methyltransferase SMYD3 2.1.1.43 0.691
4ynp SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 0.688
3fpd SAHHistone-lysine N-methyltransferase EHMT1 / 0.687
1ozv SAHRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic 2.1.1.127 0.684
3tg4 SAMN-lysine methyltransferase SMYD2 / 0.681
5hq8 SAHHistone-lysine N-methyltransferase SMYD3 2.1.1.43 0.679
3swc SAHHistone-lysine N-methyltransferase EHMT1 / 0.675
3hna SAHHistone-lysine N-methyltransferase EHMT1 / 0.669
2rfi SAHHistone-lysine N-methyltransferase EHMT1 / 0.668
4ypu SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 0.663
5f59 SAHHistone-lysine N-methyltransferase 2C 2.1.1.43 0.659
3kmt SAHHistone H3K27 methylase / 0.658
2o8j SAHHistone-lysine N-methyltransferase EHMT2 / 0.657
2igq SAHHistone-lysine N-methyltransferase EHMT1 / 0.655
4z4p SAHHistone-lysine N-methyltransferase 2D 2.1.1.43 0.652
1h8h ADPATP synthase subunit alpha, mitochondrial / 0.650
1h8h ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.650