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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3s79 ASD Aromatase 1.14.14.14

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3s79 ASDAromatase 1.14.14.14 1.096
3eqm ASDAromatase 1.14.14.14 1.069
1xf0 ASDAldo-keto reductase family 1 member C3 / 0.763
3cas ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.727
1gwr ESTEstrogen receptor / 0.720
2yja ESTEstrogen receptor / 0.716
3nhx ASDSteroid Delta-isomerase 5.3.3.1 0.715
4nky 3QZSteroid 17-alpha-hydroxylase/17,20 lyase / 0.714
4pxm ESTEstrogen receptor / 0.714
5dxg ESTEstrogen receptor / 0.707
3cot STR3-oxo-5-beta-steroid 4-dehydrogenase / 0.698
1kdk DHTSex hormone-binding globulin / 0.696
2aa5 STRMineralocorticoid receptor / 0.696
1osv CHCBile acid receptor / 0.695
1f5f DHTSex hormone-binding globulin / 0.694
3l03 4OHEstrogen receptor / 0.694
2aa6 STRMineralocorticoid receptor / 0.693
3iw1 ASDSteroid C26-monooxygenase 1.14.13.141 0.693
1d2s DHTSex hormone-binding globulin / 0.692
2qo5 CHDFatty acid-binding protein 10-A, liver basic / 0.690
3myt EQUSteroid Delta-isomerase 5.3.3.1 0.689
1kdm DHTSex hormone-binding globulin / 0.688
3gkj HC3Niemann-Pick C1 protein / 0.687
5dx3 ESTEstrogen receptor / 0.687
2cbo TH2Neocarzinostatin / 0.686
1ya3 STRMineralocorticoid receptor / 0.684
2piq DHTAndrogen receptor / 0.681
1lhu ESTSex hormone-binding globulin / 0.680
2pnu ENMAndrogen receptor / 0.678
2g5o DRQEstrogen receptor / 0.677
2qgt EEDEstrogen receptor / 0.676
4p6x HCYGlucocorticoid receptor / 0.676
2aa7 1CAMineralocorticoid receptor / 0.675
2piu DHTAndrogen receptor / 0.674
3m8c EQUSteroid Delta-isomerase 5.3.3.1 0.673
4lxj LANLanosterol 14-alpha demethylase 1.14.13.70 0.673
4l1x STRAldo-keto reductase family 1 member C2 / 0.671
3nbr ASDSteroid Delta-isomerase 5.3.3.1 0.669
5hyr ESTEstrogen receptor / 0.669
4udc DEXGlucocorticoid receptor / 0.667
3bej MUFBile acid receptor / 0.666
3w1w CHDFerrochelatase, mitochondrial 4.99.1.1 0.664
1jtv TESEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.663
1lhv NOGSex hormone-binding globulin / 0.661
1ot7 CHCBile acid receptor / 0.661
2pkl DHTAndrogen receptor / 0.659
4klr CHDFerrochelatase, mitochondrial 4.99.1.1 0.657
1fm4 DXCMajor pollen allergen Bet v 1-L / 0.656
1lri CLRBeta-elicitin cryptogein / 0.655
1m2z DEXGlucocorticoid receptor / 0.655
2b1z 17MEstrogen receptor / 0.653
4xo7 ASDAldo-keto reductase family 1 member C2 / 0.653
2aba STRPentaerythritol tetranitrate reductase / 0.652
3oll ESTEstrogen receptor beta / 0.651
4j24 ESTEstrogen receptor beta / 0.651
4ofr DHTAndrogen receptor / 0.651
2vdy HCYCorticosteroid-binding globulin / 0.650
3dtc VINMitogen-activated protein kinase kinase kinase 9 2.7.11.25 0.650
4ple CPSNuclear receptor subfamily 5 group A member 2 / 0.650