Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3rhr NDP Cytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.369
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.326
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.309
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.268
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.258
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.172
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.047
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.969
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.934
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.925
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.916
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.910
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.905
4pz2 NADAldehyde dehydrogenase 2-6 / 0.901
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.896
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.889
4i8q NADPutative betaine aldehyde dehyrogenase / 0.885
4i8p NADAminoaldehyde dehydrogenase 1 / 0.881
2jg7 NADAntiquitin / 0.869
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.866
3b4w NADAldehyde dehydrogenase family protein / 0.863
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.857
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.853
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.853
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.851
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.846
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.842
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.833
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.826
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.823
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.820
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.811
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.811
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.808
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.802
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.802
1ez0 NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.797
1bpw NADBetaine aldehyde dehydrogenase 1.2.1.8 0.790
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.787
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.781
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.766
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.765
4pt0 NADAldehyde dehydrogenase / 0.758
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.755
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.751
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.749
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.749
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.748
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.745
4i3w NADAldehyde dehydrogenase (NAD+) / 0.743
4pxl NADAldehyde dehydrogenase3 / 0.743
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.742
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.742
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.740
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.740
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.740
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 0.733
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.732
1eyy NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.732
4i3v NADAldehyde dehydrogenase (NAD+) / 0.728
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.723
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.721
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.721
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.719
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.718
4i9b NADPutative betaine aldehyde dehyrogenase / 0.717
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.716
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.714
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.712
4f3x NADPutative aldehyde dehydrogenase / 0.710
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.709
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.708
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.707
3haz NADBifunctional protein PutA / 0.705
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.704
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.702
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.701
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.700
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.694
2imp NAILactaldehyde dehydrogenase 1.2.1.22 0.693
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.688
4zvy NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.685
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 0.681
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.677
4c3s NADAldehyde Dehydrogenase / 0.675
4h73 NDPAldehyde dehydrogenase / 0.666
4l2o NADAldehyde dehydrogenase, dimeric NADP-preferring / 0.660
2ilu NDPLactaldehyde dehydrogenase 1.2.1.22 0.656
2ztu NADD(-)-3-hydroxybutyrate dehydrogenase / 0.653
2aqi NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.652
2w8r ADPSuccinate-semialdehyde dehydrogenase, mitochondrial 1.2.1.24 0.652